| It has a lot of locks | 21 |
| It connects Albany and Buffalo | 30 |
| Early 19th-century engineering marvel | 37 |
| De Witt Clinton's pet project | 33 |
| Construction with many locks | 28 |
| Construction project that began in Rome | 39 |
| Clinton supported it | 20 |
| Clinton had a big role in its construction | 42 |
| Albany/Buffalo connector | 24 |
| Albany-Buffalo waterway | 23 |
| 363-mile project known as Clinton's Folly | 45 |
| "Albany to Buffalo" waterway celebrated in song | 57 |
| Part of Gannon U.'s address | 31 |
| Home of Gannon Univ. | 20 |
| Port in the Keystone St. | 24 |
| Port ENE of Cleveland, O. | 25 |
| Great Lakes port, for short | 27 |
| Part of a postal address for Gannon University | 46 |
| Part of a postal address for Gannon Univ. | 41 |
| Line on a letter to Presque Isle Bay | 36 |
| Keystone St. city | 17 |
| It's SW of Buffalo | 22 |
| It's ENE of Cleveland | 25 |
| Home of Perry's "USS Niagara" | 43 |
| City near Buffalo, NY | 21 |
| City named for a lake: Abbr. | 28 |
| City down the lake from Buffalo, N.Y. | 37 |
| 16501 | 5 |
| U. S. Indians | 13 |
| New York tribe | 14 |
| Native New Yorkers | 18 |
| Iroquoians | 10 |
| Great Lakes Indians | 19 |
| Ohio natives | 12 |
| Eastern Indians | 15 |
| Some native New Yorkers | 23 |
| Iroquoian Indians | 17 |
| American Indians | 16 |
| Iroquois foes | 13 |
| Cat Nation members | 18 |
| New York Indians | 16 |
| Great Lakes tribesmen | 21 |
| Some Iroquoians | 15 |
| N.Y. Indians | 12 |
| Lake Indians | 12 |
| Hurons' kin | 15 |
| Great Lakes natives | 19 |
| Early Iroquois foes | 19 |
| Some Iroquois | 13 |
| Some American Indians | 21 |
| Ohio Indians, in the past | 25 |
| N. Y. Indians | 13 |
| Longhouse dwellers | 18 |
| Lakeshore natives | 17 |
| Iroquois' foes | 18 |
| Iroquoian tribe members | 23 |
| Hurons' cousins | 19 |
| Great Lakes Native Americans | 28 |
| Foes of the Senecas | 19 |
| Cherokees' kin | 18 |
| Certain Iroquoians | 18 |
| Victims of the Iroquois | 23 |
| The "Long Tails" | 26 |
| Suffixes with rook and cook | 27 |
| Some original New Yorkers | 25 |
| Some Iroquoian Indians | 22 |
| Rivals of the Iroquois | 22 |
| People with longhouses, once | 28 |
| People of the Nation du Chat | 28 |
| Onetime Ohioans | 15 |
| Onetime New York natives | 24 |
| Old Great Lakes natives | 23 |
| Northern tribesmen | 18 |
| Northeastern natives | 20 |
| Northeastern Indians | 20 |
| Neighbors of the Hurons | 23 |
| Natives of NE U.S. | 18 |
| Native Americans of Ontario and New York | 40 |
| Native Americans for whom a lake was named | 42 |
| Lake tribes | 11 |
| Kin of the Senecas | 18 |
| Iroquois tribespeople | 21 |
| Iroquois members | 16 |
| Iroquoian tribesmen | 19 |
| Indians with poisoned arrows | 28 |
| Indians of New York | 19 |
| Indians nicknamed "Cat people" | 40 |
| Indians known as the Cat People | 31 |
| Hurons' neighbors | 21 |
| Hurons' kin | 16 |
| Huron neighbors | 15 |
| Group whose name means "wild cats" | 44 |
| Great Lakes people | 18 |
| Foe of the Senecas | 18 |
| Extinct tribe | 13 |
| Extinct Ohio-N.Y. group | 23 |
| Eponyms for a canal | 19 |
| Eastern tribesmen | 17 |
| Eastern tribe members | 21 |
| Early New Yorkers | 17 |