| Indian tribe | 12 |
| Canal completed in 1825 | 23 |
| Buffalo shore | 13 |
| Where Perry triumphed | 21 |
| Welland Canal terminus | 22 |
| Toledo's waterfront | 23 |
| Spooky-sounding lake | 20 |
| Small Great Lake | 16 |
| Pennsylvania port city | 22 |
| One of the Great ones | 21 |
| Niagara Falls feeder | 20 |
| Iroquois foe | 12 |
| Iroquois enemies | 16 |
| Iroquoian tribe | 15 |
| Iroquoian people | 16 |
| Indian tongue | 13 |
| HOMES part | 10 |
| HOMES member | 12 |
| Great Lakes city | 16 |
| Great Lake touching four states | 31 |
| Fourth largest of the Great Lakes | 33 |
| Clinton's waterway | 22 |
| City on its own Great Lake | 26 |
| City near Buffalo | 17 |
| Canal to the Hudson River | 25 |
| Canal to Buffalo | 16 |
| Buffalo's waterfront | 24 |
| An Iroquoian | 12 |
| Albany's canal | 18 |
| Where Oliver Hazard Perry prevailed | 35 |
| View from Cleveland | 19 |
| The shallowest Great Lake | 25 |
| The Cat Nation | 14 |
| Stop on Amtrak's Lake Shore Limited | 39 |
| Source of the Niagara River | 27 |
| Put-in-Bay's lake | 21 |
| Pennsylvania lake port | 22 |
| Pennsylvania city, or its lake | 30 |
| One of five Great ones | 22 |
| One of a watery quintet | 23 |
| Ohio county | 11 |
| Northern terminus of I-79 | 25 |
| New York's ___ Canal | 24 |
| Lorain's lake | 17 |
| Lake bordering Ohio | 19 |
| Jay Gould's railroad | 24 |
| HOMES component | 15 |
| Fourth-largest Great Lake | 25 |
| Detroit River's destination | 31 |
| Buffalo's body of water | 27 |
| Buffalo water | 13 |
| Big lake | 8 |
| "... 15 miles on the ___ Canal" | 41 |
| View from Buffalo | 17 |
| U.S. port, or its locale | 24 |
| U.S. lake | 9 |
| Tribe once found around Buffalo | 31 |
| Toledo's water | 18 |
| The "E" in HOMES | 26 |
| Superior relative? | 18 |
| Site of Mercyhurst College | 26 |
| Sandusky sight | 14 |
| Railroad directed by Jay Gould | 30 |
| Pennsylvania county | 19 |
| Part of Ohio's border | 25 |
| Ohio's Great Lake | 21 |
| Ohio tribe | 10 |
| Niagara River feeder | 20 |
| Neighbour of Ontario | 20 |
| Neighbour of Huron | 18 |
| Lake tribe | 10 |
| Lake southwest of Lake Ontario | 30 |
| Lake named for an Indian tribe | 30 |
| Lackawanna's partner | 24 |
| Jolliet's 1669 discovery | 28 |
| Home of Gannon University | 25 |
| Enemies of the Iroquois | 23 |
| Eastern tribe | 13 |
| Detroit River outlet | 20 |
| Cuyahoga's outlet | 21 |
| Clinton's "Big Ditch" | 35 |
| City SW of Buffalo | 18 |
| City southwest of Buffalo | 25 |
| City or lake | 12 |
| City on Presque Isle Bay | 24 |
| Cat Nation people | 17 |
| Canal opened in 1825 | 20 |
| Buffalo-to-Albany canal | 23 |
| Ashtabula's waterfront | 26 |
| American lake | 13 |
| Albany canal | 12 |
| 1813 battle site | 16 |
| ". . . fifteen miles on the ___ Canal" | 48 |
| ___-Lackawanna Railroad | 23 |
| ___ Lackawanna Railroad | 23 |
| Western New York county | 23 |
| War of 1812 locale | 18 |
| View from Sandusky, Ohio | 24 |
| Strange-sounding lake | 21 |
| Storied canal | 13 |