| Canal or railroad | 17 |
| Canal or port | 13 |
| Canal or county in N.Y. | 23 |
| Canal of songdom | 16 |
| Canal of Sal | 12 |
| Canal near Rome | 15 |
| Canal mentioned in the song “Low Bridge, Everybody Down” | 64 |
| Canal in the Ramones' home state | 36 |
| Canal in a song | 15 |
| Canal from the Great Lakes to the Atlantic Ocean | 48 |
| Canal from the Great Lakes to the Atlantic | 42 |
| Canal from the Great Lakes | 26 |
| Canal for Sal, in a song | 24 |
| Canal depicted on New York's state quarter | 46 |
| Canal called "Clinton's Folly" | 44 |
| Canal by Buffalo | 16 |
| Canal backed by DeWitt Clinton | 30 |
| Canal at Albany | 15 |
| Canada's Battle of Fort ___, 1866 | 37 |
| Buffalo's waters | 20 |
| Buffalo's vista | 19 |
| Buffalo's lake and county | 29 |
| Buffalo's country | 21 |
| Buffalo's canal | 19 |
| Buffalo's backdrop | 22 |
| Buffalo-to-Albany watercourse | 29 |
| Buffalo lake | 12 |
| Buffalo is on its shore | 23 |
| Buffalo body | 12 |
| Buckeye State county | 20 |
| Body that sounds scary | 22 |
| Body of water near Buffalo | 26 |
| Body Joliet sighted | 19 |
| Birthplace of Billy Blanks | 26 |
| Big name in railroads | 21 |
| Big name in railroading | 23 |
| Behrend College locale | 22 |
| Battle site: Sept. 10, 1813 | 27 |
| Battle site: 1813 | 17 |
| Battle site of 1813 | 19 |
| Base for Commodore Perry | 24 |
| Barge canal in N.Y. | 19 |
| Ashtabula's water | 21 |
| Ashtabula waterfront | 20 |
| Ashtabula abuts it | 18 |
| Another Pa. city | 16 |
| An Iroquoian map | 16 |
| Amerind or canal | 16 |
| American lake every constructor is sick of cluing, and "American lake" was probably enough to give it to you, so screw it | 131 |
| Albany-to-Buffalo route | 23 |
| Albany-Buffalo canal | 20 |
| A neighbor of Huron | 19 |
| A lake or canal | 15 |
| A body on Canada's southern border | 38 |
| A "long tail" | 23 |
| 19th century canal name | 23 |
| 1960 railroad merger company | 28 |
| 1825 canal | 10 |
| 1813's Battle of Lake ___ | 29 |
| 1813 naval battle site | 22 |
| 1669 sight for Louis Jolliet | 28 |
| 1669 Louis Jolliet discovery | 28 |
| 15 miles of it are mentioned in a song | 38 |
| "We have met the enemy" there | 39 |
| "Walleye Capital of the World" | 40 |
| "that thing you do!" setting | 38 |
| "Low bridge! Everyone down!" canal | 44 |
| "Lake effect snow" city | 33 |
| "Dead Sea" of U.S. | 28 |
| "Clinton's ditch" | 31 |
| "Clinton's canal" | 31 |
| "15 miles on the ___ Canal" | 37 |
| ''Clinton's Ditch'' | 39 |
| -- Canal | 8 |
| _____Canal | 10 |
| _____ Lackawanna Railway | 24 |
| ___ Railroad, founded 1832 | 26 |
| ___ Railroad, 1832-1960 | 23 |
| ___ Railroad Co. v. Tompkins (1938 Supreme Court decision) | 58 |
| ___ quenelle (Pa. poached dumpling?) | 36 |
| ___ Lackawanna (bygone railroad) | 32 |
| ___ Lackawanna | 14 |
| ___ Canal, waterway through Schenectady | 39 |
| __ Lackawanna Railway | 21 |
| __ Lackawanna Railroad | 22 |
| __ Canal | 8 |
| It opened in 1825 | 17 |
| Waterway engineered by Clinton | 30 |
| It has many locks | 17 |
| Work on it began in Rome in 1817 | 32 |
| Waterway with many locks | 24 |
| Waterway that's 363 miles long | 34 |
| Vital man-made link in New York | 31 |
| The Seneca Chief was the first vessel to travel its entire length | 65 |
| The Seneca Chief was the first to travel its full length | 56 |
| Storied waterway | 16 |
| Pet project of De Witt Clinton | 30 |
| New York waterway | 17 |
| Line on New York's state quarter | 36 |
| It includes 36 locks | 20 |