| Port of entry in Pa. | 20 |
| Port north of Meadville | 23 |
| Port in Pennsylvania | 20 |
| Port in Pa. | 11 |
| Port 'twixt Buffalo and Cleveland | 37 |
| Perry's victory site | 24 |
| Perry's lake | 16 |
| Perry's headquarters | 24 |
| Perry's conquest | 20 |
| Perry victory site | 18 |
| Perry Square locale | 19 |
| Perry locale | 12 |
| Perry battle site | 17 |
| Pennsylvania's only Great Lakes port | 40 |
| Pennsylvania's northernmost county | 38 |
| Pennsylvania's lake port | 28 |
| Pennsylvania's fourth largest city | 38 |
| Pennsylvania's "Flagship City" | 44 |
| Pennsylvania lake | 17 |
| Pennsylvania industrial center | 30 |
| Pennsylvania county, or its lake | 32 |
| Pennsylvania county that borders New York and Ohio | 50 |
| Pennsylvania county or its seat | 31 |
| Pennsylvania city whose motto is "Feel the Lake Effect" | 65 |
| Pennsylvania city where Billy Blanks was born | 45 |
| Pennsylvania city or county | 27 |
| Pennsylvania city on a same-named lake | 38 |
| Pennsylvania city of about 100,000 | 34 |
| Pennsyl-vania port | 18 |
| Penn State city | 15 |
| Penn State branch site | 22 |
| Part of the U.S./Canada border | 30 |
| Part of the HOMES mnemonic | 26 |
| Part of Ontario's southern border | 37 |
| Part of N.Y. State Barge Canal | 30 |
| Part of a wet quintet | 21 |
| Part of "H.O.M.E.S." | 30 |
| Pa.'s only Great Lakes port | 31 |
| Pa. port of entry | 17 |
| Pa. lakeside city | 17 |
| Pa. lake port | 13 |
| Pa. county | 10 |
| Ontario's Fort ___ | 22 |
| Ontario-Huron link | 18 |
| Ontario feeder | 14 |
| Only four-letter Great Lake | 27 |
| Onetime New York Indian | 23 |
| One of the Niagara River's sources | 38 |
| One of the Lower Lakes | 22 |
| One of the HOMES lakes | 22 |
| One of the HOMES | 16 |
| One of the five "Greats" | 34 |
| One of the "Long Tails" | 33 |
| One of the "Great" ones | 33 |
| One of five on a map | 20 |
| One of five lakes | 17 |
| One of five great waterways | 27 |
| One of five expanses | 20 |
| One of five bodies | 18 |
| One of five "Greats" | 30 |
| One of a well-known quintet | 27 |
| One of a lake quintet | 21 |
| One of "H.O.M.E.S." | 29 |
| Oliver Perry victory site | 25 |
| Oliver Hazard Perry victory site | 32 |
| Old Ohio/New York tribe | 23 |
| Old name in railroading | 23 |
| Old Buffalo-to-Albany canal | 27 |
| Ohio/Ontario separator | 22 |
| Ohio-Ontario separator | 22 |
| Ohio Indian, once | 17 |
| Ohio Indian | 11 |
| Ohio county north of Huron | 26 |
| NY canal | 8 |
| Northwesternmost Pennsylvania county | 36 |
| Northwesternmost county in Pennsylvania | 39 |
| Northwestern Pennsylvania county | 32 |
| Northern waterway | 17 |
| Northeastern canal | 18 |
| Northeast Indian | 16 |
| North American language | 23 |
| Niagara River's feeder | 26 |
| New York's shortest-named county | 36 |
| New York's most populous upstate county | 43 |
| New York's __ Canal | 23 |
| New York tribe defeated by the Iroquois | 39 |
| New York State's ___ Canal | 30 |
| New York and ___ Railroad, started in 1832 | 42 |
| Neighbour of Ontario | 22 |
| Neighbor of Ontario | 19 |
| Neighbor of Chautauqua Lake | 27 |
| Naval battle site: 1813 | 23 |
| Naval battle site of 1813 | 25 |
| Name of counties in three states, all crossed by I-90 | 53 |
| N.Y. Indian | 11 |
| N. Y. canal | 11 |
| Most populous county in upstate New York | 40 |
| Most of Ohio's northern boundary | 36 |
| Mohawk's relative | 21 |
| Mercyhurst University's city | 32 |