| Mercyhurst College city | 23 |
| Mentor-on-the-Lake's lake | 29 |
| Maumee's outlet | 19 |
| Major U.S. lake | 15 |
| Losing tribe in the Beaver Wars | 31 |
| Lorain, Ohio's lake | 23 |
| Large North American lake | 25 |
| Large lake | 10 |
| Language related to Wyandot | 27 |
| Lakewood, Ohio's lake | 25 |
| Lakeside Pennsylvania city | 26 |
| Lakes tribe | 11 |
| Lakes Indian | 12 |
| Lake-effect snow city | 21 |
| Lake where Perry prevailed in 1813 | 34 |
| Lake where Perry achieved an 1813 victory | 41 |
| Lake visible from the Rock and Roll Hall of Fame | 48 |
| Lake visible from Cedar Point amusement park | 44 |
| Lake that's the outlet for the Detroit River | 48 |
| Lake that touches New York and Ontario | 38 |
| Lake that sounds spooky | 23 |
| Lake that Ohio's Lake County borders | 40 |
| Lake that flows into the Niagara River | 38 |
| Lake that contains Canada's southernmost point | 50 |
| Lake that borders Ohio | 22 |
| Lake surrounding Pelee Island | 29 |
| Lake surrounding Kelleys Island | 31 |
| Lake south of Niagara Falls | 27 |
| Lake site of a War of 1812 battle | 33 |
| Lake separated from Lake Ontario by the Niagara River | 53 |
| Lake seen from Monroe, Michigan | 31 |
| Lake seen from Euclid, Ohio | 27 |
| Lake seen at Lakewood, Ohio | 27 |
| Lake or tribe | 13 |
| Lake or port | 12 |
| Lake on the U.S.-Canadian boundary | 34 |
| Lake on the Pennsylvania coast | 30 |
| Lake on our northern border | 27 |
| Lake on four states and a province | 34 |
| Lake of the Bass Islands | 24 |
| Lake not far from Niagara Falls | 31 |
| Lake north of Cleveland | 23 |
| Lake next to Cleveland | 22 |
| Lake next to Cedar Point amusement park | 39 |
| Lake next to Avon Lake | 22 |
| Lake near London | 16 |
| Lake near Lake Ontario | 22 |
| Lake near Jacobs Field | 22 |
| Lake near Cleveland | 19 |
| Lake into which Ohio's Cuyahoga River empties | 49 |
| Lake in U.S. and Canada | 23 |
| Lake in four states and Canada | 30 |
| Lake in an old railroad name | 28 |
| Lake from which the Niagara River flows | 39 |
| Lake fed by the Sandusky River | 30 |
| Lake fed by the Maumee River | 28 |
| Lake fed by the Maumee | 22 |
| Lake fed by the Detroit River | 29 |
| Lake fed by the Cuyahoga River | 30 |
| Lake depicted on Michigan's state quarter | 45 |
| Lake connected to Sandusky Bay | 30 |
| Lake city | 9 |
| Lake by the Rock and Roll Hall of Fame | 38 |
| Lake bordering New York | 23 |
| Lake bordering four states | 26 |
| Lake between Ontario and Huron | 30 |
| Lake between Ohio and Ontario | 29 |
| Lake at southernmost point of Canada | 36 |
| Lake at SE Mich. | 16 |
| Lake along which I-90 runs | 26 |
| Lake adjoining Ontario | 22 |
| Lake adjacent to the Rock and Roll Hall of Fame | 47 |
| Lake above Ontario | 18 |
| Lake ___, south of London | 25 |
| Lake ___, source of the Niagara River | 37 |
| Lake ___, home of the Bass Islands | 34 |
| Lake ___, discovery of Louis Jolliet | 36 |
| Lake ___, 1813 battle site | 26 |
| Lake ___ Beach, N.Y. | 20 |
| Lake __ College, near Cleveland | 31 |
| Lackawanna's railroad partner | 33 |
| Lackawanna's partner in railroads | 37 |
| Lackawanna's partner in railroading | 39 |
| Lackawanna partner | 18 |
| Keystone State county | 21 |
| Jay Gould's train company | 29 |
| Jay Gould's railroad: 1867–72 | 40 |
| Jay Gould's railroad, once | 30 |
| It's part of four states' borders | 41 |
| It's fed by the Cuyahoga | 28 |
| It's due north of Pittsburgh | 32 |
| It's between Huron and Ontario | 34 |
| It's at one end of I-79 | 27 |
| It's about 115 miles north of Pittsburgh | 44 |
| Iroquois foe in the Beaver Wars | 31 |
| Iroquois enemy | 14 |
| Indians' lake | 17 |
| Indian or canal | 15 |
| Indian of the Great Lakes region | 32 |
| Indian of a New York region | 27 |