| Spooky waterway? | 16 |
| Southernmost of the Great Lakes | 31 |
| Soprano Mills | 13 |
| Smallest Great Lake, in volume | 30 |
| Smallest Great Lake, by volume | 30 |
| Site of Villa Maria College | 27 |
| Sight from Buffalo | 18 |
| Seneca foe | 10 |
| Railroad chartered in 1832 | 26 |
| Puzzler | 7 |
| Presque Isle's lake | 23 |
| Port on its own lake | 20 |
| Port city or the lake it's on | 33 |
| Ontario's neighbor | 22 |
| One of a noted quintet | 22 |
| Old railroad name | 17 |
| Ohio-Ontario divider | 20 |
| Northeastern U.S. canal | 23 |
| North American lake | 19 |
| Niagara source | 14 |
| Name of a lake or canal | 23 |
| N.Y. county | 11 |
| Mule Sal's canal | 20 |
| Maumee Bay feeder | 17 |
| Louis Jolliet discovery of 1669 | 31 |
| Lake the Detroit River flows into | 33 |
| Lake that the Huron River flows into | 36 |
| Lake that feeds Niagara Falls | 29 |
| Lake or Indian | 14 |
| Lake north of Ohio | 18 |
| Lake named after an Indian tribe | 32 |
| Lake Indian | 11 |
| Lake feeding the Niagara River | 30 |
| Lake bordering Ontario | 22 |
| Lake ___, outlet of the Maumee River | 36 |
| Jay Gould railroad | 18 |
| It's inferior to Superior | 29 |
| Iroquois | 8 |
| Historic canal | 14 |
| Great one? | 10 |
| Gannon University site | 22 |
| Fort __, Ontario | 16 |
| Former lakeshore tribe | 22 |
| Foe of the Iroquois | 19 |
| Foe of a Seneca | 15 |
| First American canal | 20 |
| Fabled canal | 12 |
| Empire State canal | 18 |
| Commodore Perry's headquarters | 34 |
| Cleveland Indian | 16 |
| City near Presque Isle State Park | 33 |
| City in Penna. | 14 |
| Canal with a mule, in song | 26 |
| Canal to the Hudson | 19 |
| Canal or Indian | 15 |
| Canal or city | 13 |
| Canal from Albany | 17 |
| Border water | 12 |
| Battle of Lake ___: 1813 | 24 |
| Admiral Perry victory site | 26 |
| "... fifteen miles on the ___ Canal" | 46 |
| Wyandot's cousin | 20 |
| Where the Detroit River ends | 28 |
| Where Perry prevailed | 21 |
| Welland Canal outlet | 20 |
| Warmest of the Great Lakes | 26 |
| War of 1812 siege site | 22 |
| Villa Maria College site | 24 |
| View from Sandusky | 18 |
| View from Presque Isle State Park | 33 |
| Tribe whose name means "long tail" | 44 |
| Tribe defeated by the Iroquois | 30 |
| Tribe also called the Cat Nation | 32 |
| The ''E'' in HOMES | 34 |
| Strange-sounding waterway? | 26 |
| Strange-sounding city? | 22 |
| Strange-sounding canal? | 23 |
| Springsteen's Seeger cover "___ Canal" | 52 |
| Source of the Niagara | 21 |
| Sight from Toledo | 17 |
| Sight from the Rock and Roll Hall of Fame | 41 |
| Sight from Cleveland | 20 |
| Seneca's foe | 16 |
| Scene of Perry's victory | 28 |
| Scary-sounding lake | 19 |
| Sandusky Bay lake | 17 |
| Presque Isle State Park's lake | 34 |
| Presque Isle locale | 19 |
| Presque Isle lake | 17 |
| Port city of Pennsylvania | 25 |
| Pennsylvania's northwesternmost county | 42 |
| Pennsylvania's Great Lakes port | 35 |
| Pennsylvania's fourth-largest city | 38 |
| Pennsylvania's Flagship City | 32 |
| Pennsylvania port or its lake | 29 |
| Pennsylvania or New York county | 31 |
| Pennsylvania neighbor | 21 |
| Pelee Island's lake | 23 |
| Part of Pennsylvania's border | 33 |
| PA port | 7 |