| O3 | 2 |
| Refreshing air | 14 |
| Layer with a hole in it | 23 |
| Kind of hole or layer | 21 |
| Imperiled layer | 15 |
| Gas in a layer | 14 |
| Fragile atmosphere layer | 24 |
| Damaged layer | 13 |
| UV stopper | 10 |
| UV ray absorber | 15 |
| Upper atmosphere layer | 22 |
| Ultraviolet light filter | 24 |
| Ultraviolet blocker | 19 |
| Thunderstorm product | 20 |
| Thunderstorm byproduct | 22 |
| Lightning byproduct | 19 |
| Layer up high | 13 |
| Kind of hole | 12 |
| Endangered atmospheric layer | 28 |
| Clear air | 9 |
| Atmosphere layer | 16 |
| __ layer | 8 |
| UV blocker | 10 |
| Upper atmospheric layer | 23 |
| Ultraviolet ray blocker | 23 |
| Triatomic molecule | 18 |
| Ray blocker | 11 |
| Pale-blue gas | 13 |
| One of the greenhouse gases | 27 |
| Much-discussed layer | 20 |
| Gas in the stratosphere | 23 |
| Environmentalists' concern | 30 |
| Eco-worry | 9 |
| Earth protector | 15 |
| Depleted layer | 14 |
| Contents of a sensitive layer | 29 |
| Certain atmospheric layer | 25 |
| Bluish gas | 10 |
| Atmospheric layer with a "hole" in it | 47 |
| Atmospheric layer of note | 25 |
| Atmospheric gas | 15 |
| Atmospheric concern | 19 |
| Allotrope of oxygen | 19 |
| A layer with a hole | 19 |
| ___ layer (upper atmosphere part) | 33 |
| ___ hole | 8 |
| What CFC's deplete | 22 |
| Water sterilizer | 16 |
| UV ray blocker | 14 |
| UV filterer | 11 |
| Ultraviolet-ray blocker | 23 |
| Ultraviolet rays absorber | 25 |
| Ultraviolet radiation absorber | 30 |
| Ultraviolet Index factor | 24 |
| Ultraviolet filterer | 20 |
| Trioxygen molecule | 18 |
| Triatomic pollutant | 19 |
| Triatomic oxygen molecule | 25 |
| Triatomic oxygen | 16 |
| Triatomic greenhouse gas | 24 |
| Triatomic gas in a thinning layer ... and, symbolically, what appears in this puzzle's four longest answers | 111 |
| Triatomic gas | 13 |
| Triatomic form of oxygen | 24 |
| Triatomic form of element #8 | 28 |
| Thunderstorm residue | 20 |
| Threatened layer | 16 |
| Threatened atmosphere layer | 27 |
| Thinning layer | 14 |
| Thinning atmospheric layer | 26 |
| Swimming-pool sanitizer | 23 |
| Subject of environmentalist study | 33 |
| Stratospheric layer | 19 |
| Stratospheric gas | 17 |
| Stratosphere layer | 18 |
| Stratosphere gas | 16 |
| Spa sanitizer | 13 |
| Site of a worrisome hole | 24 |
| Sensitive layer | 15 |
| Radiation-reducing layer | 24 |
| Radiation reducer | 17 |
| Protection around the world? | 28 |
| Photochemical smog component | 28 |
| Part of the stratosphere | 24 |
| Pale blue gas | 13 |
| Oxygen allotrope | 16 |
| Odorous oxygen | 14 |
| O-O-O | 5 |
| Molecule also called trioxygen | 30 |
| Low-level pollution or high-level protection | 44 |
| Lightning strike by-product | 27 |
| Layer with holes | 16 |
| Layer with a problematic hole | 29 |
| Layer with a ''hole'' | 37 |
| Layer with "holes" in it | 34 |
| Layer to worry about | 20 |
| Layer to be concerned about | 27 |
| Layer that filters out UV rays | 30 |
| Layer that absorbs ultraviolet rays | 35 |
| Layer of concern | 16 |
| Layer in the atmosphere | 23 |