| Pope when the Visigoths seized Rome | 35 |
| In a dewy-eyed way | 18 |
| 2006 non-fiction work, with "The" | 43 |
| With ''The'', Twain book | 40 |
| Twain title, with "The" | 33 |
| Twain book | 10 |
| Book by Twain | 13 |
| 1869 Twain novel, with "The" | 38 |
| Seventeenth-century pope painted by Diego Velázquez | 54 |
| Stick with a needle, maybe | 26 |
| Without identification | 22 |
| Start something new | 19 |
| Produce something new | 21 |
| Offer a new twist | 17 |
| Introduce something new | 23 |
| Pioneers | 8 |
| Does new things | 15 |
| Novelties | 9 |
| Steve Jobs, for example | 23 |
| Winters '64 and '76 | 28 |
| Winter Olympics site, 1976 | 26 |
| Two-time Winter Olympics city | 29 |
| England's ___ Court | 23 |
| English legal societies | 23 |
| Shingle on a B&B | 20 |
| Some risqué humor | 20 |
| Member of an Arctic people | 26 |
| Eskimo: var. | 12 |
| Eskimo group | 12 |
| Hypodermic fluid | 16 |
| Protect from bugs | 17 |
| Infect on purpose | 17 |
| Immunize | 8 |
| Do a travel clinician's job, say | 36 |
| Protects from disease | 21 |
| Immunity bestower of sorts | 26 |
| Not out of style? | 17 |
| Certain billiards scratch, to a Brit | 36 |
| Keep money ___-shore accounts (stash cash) | 42 |
| Politician's place | 22 |
| Governing | 9 |
| Not having ill fortune? | 23 |
| How vending machines give change | 32 |
| Suffix for alcohols | 19 |
| New wine ___ bottles | 20 |
| "And proud men ___ age . . . ": Sophocles | 51 |
| "___ NewYork," 1906 song | 34 |
| "___ New York" | 24 |
| "___ New York," 1906 song | 35 |
| "___ Chicago," 1938 movie | 35 |
| "__ Chicago": 1937 Tyrone Power film | 46 |
| 1942 John Wayne film | 20 |
| "Coming ___ wing and a prayer" | 40 |
| How some plays are performed | 28 |
| Part 2 of the pun | 17 |
| Start for "and out the other" | 39 |
| Journey start of unheeded advice | 32 |
| Counterpart of "out the other" | 40 |
| "___ and out . . . " | 30 |
| ____ and out the other | 22 |
| Together, to a launderer | 24 |
| Largely unscathed | 17 |
| Feel ___ | 8 |
| Do as a mentor did, say | 23 |
| Very pleased with oneself | 25 |
| Have ___ (know by heart) | 24 |
| Not at all buggy | 16 |
| Be a hindrance | 14 |
| Ready to pen an essay? | 22 |
| Turkish statesman | 17 |
| Turkish President | 17 |
| Turkish statesman Ismet (anagram of UNION) | 42 |
| Turkish statesman Ismet ___ | 27 |
| Turkish President: 1938-50 | 26 |
| Turkish P.M. | 12 |
| Turkey's President: 1938-50 | 31 |
| Formerly Ismet Paza | 19 |
| Ataturk's successor (anagram of UNION) | 42 |
| Atatürk's first prime minister | 37 |
| Koh-___ (diamond) | 17 |
| End of the sub-headline | 23 |
| Unsuitable for surgery | 22 |
| Unfit for use | 13 |
| Won't run | 13 |
| ... the beginning of a spy? | 27 |
| Enspheres | 9 |
| So that one might | 17 |
| So that one can | 15 |
| So that one may | 15 |
| Start of a quote by Coco Chanel | 31 |
| Some wise advice (Part 1) | 25 |
| So that one could | 17 |
| "___ form a more perfect Union ..." | 45 |
| Question, part four | 19 |
| Borrower's question (Part 4) | 32 |
| Neither plant nor animal: Abbr. | 31 |
| Like non-hydrocarbon compounds | 30 |
| Like non-carbon compounds | 25 |
| Like ammonia, chemically | 24 |
| Extraneous | 10 |