| Tom Hanks plays it | 18 |
| Tom Cruise plays it | 19 |
| Tom Collier in "The Animal Kingdom" | 45 |
| This is in a cast | 17 |
| Thespian's vehicle | 22 |
| Thespian's résumé listing | 35 |
| Thespian's "I'm on a ___!" | 44 |
| The Terminator in "The Terminator," e.g. | 50 |
| The lead, for instance | 22 |
| Thatcher, to Streep | 19 |
| Supporting __ | 13 |
| Studio listing | 14 |
| Starring or cameo | 17 |
| Starring ___ | 12 |
| Something to audition for | 25 |
| Something that's cast | 25 |
| Something cast | 14 |
| Some rockers long for a movie one | 33 |
| Snooks, to Brice | 16 |
| Show part | 9 |
| Series of lines, essentially | 28 |
| Rose Murphy, e.g. | 17 |
| Romeo or Juliet, say | 20 |
| Romeo or Juliet, for some | 25 |
| Romeo or Dromio | 15 |
| Rocky, to Stallone | 18 |
| Reading goal | 12 |
| Radamès in "Aïda," e.g. | 39 |
| Puck or Feste | 13 |
| Prescribed pattern of behavior | 30 |
| Player's persona | 20 |
| Pierce, to Alda | 15 |
| Performing job | 14 |
| Performing gig | 14 |
| Performer's job | 19 |
| Part to be played | 17 |
| Part of the movie industry? | 27 |
| Part of RPG | 11 |
| Part of a reversal, maybe | 25 |
| Part in a video | 15 |
| Part in a show | 14 |
| Part in a film | 14 |
| Part for Jannings | 17 |
| Part for Boomer | 15 |
| Part for an actor | 17 |
| Othello, to Fishburne | 21 |
| One usually involves lines | 26 |
| One may be leading or supporting | 32 |
| Mork or Mindy | 13 |
| Moe Howard, for Chris Diamantopoulos, in 2012 | 45 |
| Mme. Curie, to Garson | 21 |
| Mimi or Norma | 13 |
| Medea, for one | 14 |
| Malcolm X, for Denzel Washington | 32 |
| Maggie the Cat, e.g. | 20 |
| Macbeth or Lady Macbeth | 23 |
| Macbeth or Hamlet | 17 |
| Macbeth e.g. | 13 |
| Lorne Greene's Adama on TV | 30 |
| Loman or Lear e.g. | 19 |
| Lear or Othello | 15 |
| Leading ___ | 11 |
| Lead, perhaps | 13 |
| Lead or heavy | 13 |
| Lead or cameo | 13 |
| Lead for one | 13 |
| Lady Macbeth, today | 19 |
| Lady Macbeth, for one | 21 |
| Ladder, part 5 | 14 |
| King Henry V, e.g. | 18 |
| Jason Bourne, for Matt Damon | 28 |
| It's played on Broadway | 27 |
| It's played in a play | 25 |
| It's made to be played | 26 |
| It's cast and landed | 24 |
| It may be played for money | 26 |
| It may be played | 16 |
| It has lines | 12 |
| It gets played | 14 |
| Iron Man, to Robert Downey, Jr. | 31 |
| Ilsa, to Ingrid | 15 |
| Hunt, to Cruise | 15 |
| Hughes, for DiCaprio | 20 |
| Hoffman's Tootsie, e.g. | 27 |
| Histrion's delight | 22 |
| Histrio's need | 18 |
| Heavy, say | 10 |
| Heavy, e.g. | 11 |
| Hat to wear, so to speak | 24 |
| Hamlet, to Olivier | 18 |
| Hamlet, in "Hamlet" | 29 |
| Hamlet or Macbeth | 17 |
| Hamlet is one | 13 |
| Gwenn's Kringle in a 1947 film | 34 |
| Gump, to Hanks | 14 |
| Gremio or Grumio | 16 |
| God, for George Burns or Morgan Freeman | 39 |
| Goal of a tryout | 16 |
| Goal for an auditioner | 22 |
| Geller, to Schwimmer | 20 |