| "No ___, no gain" | 27 |
| Irksome sort | 12 |
| Cause of a wince | 16 |
| Bread, in Brest | 15 |
| Bodily distress | 15 |
| __ in the neck (pest) | 21 |
| Unpleasant sensation | 20 |
| This may stab or shoot | 22 |
| There's no gain without it | 30 |
| Suffering's partner, in court | 33 |
| Stitch, e.g. | 12 |
| Royal annoyance | 15 |
| Prerequisite for a weightlifter's gain? | 43 |
| Physical suffering | 18 |
| Ouch inducer | 12 |
| Joy's antithesis | 20 |
| Endorphins producer | 19 |
| Emotional distress | 18 |
| Cause to grimace | 16 |
| Anodyne's target | 20 |
| "Sweet is pleasure after ___": Dryden | 47 |
| Young brother, often | 20 |
| World of hurt | 13 |
| What lines with stars at the end indicate in comics | 51 |
| What dols measure | 17 |
| What an analgesic stops | 23 |
| What a French baker produces | 28 |
| What a dolorimeter measures | 27 |
| That hurts | 10 |
| T-___ (noted Auto-Tune user) | 28 |
| Strong discomfort | 17 |
| Some athletes play through it | 29 |
| Sibling, at times? | 18 |
| Result of punishment | 20 |
| Requisite for gain, so they say | 31 |
| Reliever's target | 21 |
| Reason to take acetaminophen | 28 |
| Reason for a clinic visit | 25 |
| Proverbial problem for the neck or butt | 39 |
| Pesky one | 9 |
| Percocet's target | 21 |
| Ouch's cause | 16 |
| Number's target? | 20 |
| Nuisance, so to speak | 21 |
| Nice bread | 10 |
| Neuralgia | 9 |
| Neck affliction | 15 |
| Little brother, at times | 24 |
| It might be in the neck | 23 |
| It may be unbearable | 20 |
| It can follow a fall | 20 |
| It can be chronic or shooting | 29 |
| It "clings cruelly to us," according to Keats | 55 |
| Hardly pleasure | 15 |
| Grimace inducer | 15 |
| Gagne ___ (French breadwinner) | 30 |
| Feeling that makes you say "Ow!" | 42 |
| Excedrin target | 15 |
| Clubber Lang's prediction for Rocky | 39 |
| Clinton felt yours | 18 |
| Bread, in Bruxelles | 19 |
| Bread, in Bayonne | 17 |
| Bread in Brest | 15 |
| Baby brother, often | 19 |
| Arduous chore | 13 |
| Ache's cousin | 17 |
| "Royal" nuisance | 26 |
| "Royal" annoyance | 27 |
| "Our Lady of ___": Swinburne | 38 |
| "No __, no gain" | 26 |
| "No ___, no gain" (gym saying) | 40 |
| "I feel your __" | 26 |
| ___ in the ass | 14 |
| "Common Sense" author | 31 |
| "Common Sense" pamphleteer | 36 |
| TOM | 3 |
| Common Sense author | 22 |
| "Common Sense" writer | 31 |
| "The Age of Reason" author Thomas | 43 |
| "Common Sense" man | 28 |
| 'Common Sense' writer | 29 |
| Author of "Common Sense" | 34 |
| "The Age of Reason" author | 36 |
| Early American pamphleteer | 26 |
| "Rights of Man" writer | 32 |
| "Rights of Man" author | 32 |
| "Common Sense" pamphleteer Thomas | 43 |
| Thomas who wrote "Common Sense" | 41 |
| Thomas of ''The Age of Reason'' | 47 |
| Patriot Tom | 11 |
| Pamphleteer Thomas | 18 |
| He wrote "Common Sense" | 33 |
| Founding Father who wrote "Rights of Man" | 51 |
| Early pamphleteer | 17 |
| Citizen Tom | 11 |
| Author of "The Age of Reason" | 39 |
| Activist admired by Edison | 26 |
| "These are the times that try men's souls" writer | 63 |
| "The Rights of Man" writer | 36 |
| "The Rights of Man" author | 36 |