| Nero's 1,502 | 16 |
| Early 16th-century year | 23 |
| Caesar's 1502 | 17 |
| 1502, on a monument | 19 |
| Year Michelangelo's "David" was completed | 55 |
| 1504, to Caesar | 15 |
| Year Columbus returned from his final voyage to the New World | 61 |
| XII years after Columbus's first voyage | 43 |
| XII years after Columbus's famous voyage | 44 |
| Twice DCCLII | 12 |
| MMMVIII ÷ II | 15 |
| DCCLII doubled | 14 |
| Year Helsinki was founded | 25 |
| Year in the reign of Edward VI | 30 |
| Start of Julius III's papacy | 32 |
| Mid-16th century date | 21 |
| L x XXXI | 8 |
| 1550 | 4 |
| Year Nostradamus's first almanac was written | 48 |
| Year in the reign of Ivan the Terrible | 38 |
| Year in the life of Nostradamus | 31 |
| Year Charles IX was born | 24 |
| The year 1550 | 13 |
| Roman 1,550 | 11 |
| Nero's 1550 | 15 |
| Monumental 1550 | 15 |
| Middle of the 16th century | 26 |
| Middle of 16th century | 22 |
| Midcentury year | 15 |
| Half of MMMC | 12 |
| CCCX x V | 8 |
| Cato's 1,550 | 16 |
| Caesar's 1550 | 17 |
| Caesar's 1,550 | 18 |
| 1550, to Flavius | 16 |
| 1550, in old Rome | 17 |
| 1551, on monuments | 18 |
| Year the National University of Mexico was founded | 50 |
| Roman numeral that translates to a 4-digit palindrome | 53 |
| Year the oldest college in the Americas was founded, in Mexico City | 67 |
| Year of Boris Godunov's birth | 33 |
| Year in Ivan the Terrible's reign | 37 |
| Year Boris Godunov was born | 27 |
| Year before Raleigh's birth | 31 |
| The year 1551 | 13 |
| Roman 1551 | 10 |
| Mid 16th-century year | 21 |
| Livy's 1,551 | 16 |
| Half of MMMCII | 14 |
| DXVII x III | 11 |
| 1551, in monuments | 18 |
| 16th-century yr. | 16 |
| 1555, to Caesar | 15 |
| Some hosp. employees | 20 |
| "ER" roles | 20 |
| Rx prescribers | 14 |
| ER VIPs | 7 |
| Some ER staffers | 16 |
| ER bosses | 9 |
| "St. Elsewhere" roles | 31 |
| Some Johns Hopkins grads | 24 |
| Hosp. people | 12 |
| GPs | 3 |
| Scrip writers | 13 |
| Puzzle title people hidden in eight long answers | 48 |
| Prescription writers: Abbr. | 27 |
| Physicians (abbr.) | 18 |
| Ones in residency: Abbr. | 24 |
| Doctors' degrees | 20 |
| "Tender Love" Force ___ | 33 |
| "Grey's Anatomy" roles | 36 |
| Ward workers, for short | 23 |
| Ward healers? (Abbr.) | 21 |
| TV's House and Howser, for two | 34 |
| TV's House and Howser | 25 |
| Treating people, briefly | 24 |
| This puzzle's theme involves four TV ones | 45 |
| They work in ERs | 16 |
| They request ECGs and MRIs | 26 |
| Some operators: Abbr. | 21 |
| Some exam givers, for short | 27 |
| Some exam administrators | 24 |
| Some "General Hospital" roles, in brief | 49 |
| Script writers: Abbr. | 21 |
| Scrip writers: Abbr. | 20 |
| Scrip writers (abbr.) | 21 |
| Rx signers | 10 |
| RNs' coworkers | 18 |
| RNs' co-workers | 19 |
| Residents, e.g., at the hosp. | 29 |
| Readers of MRI results | 22 |
| Prescription writers | 20 |
| Practitioners, for short | 24 |
| Physicians' degrees: Abbr. | 30 |
| Physicians, letter-wise | 23 |
| PCPs, e.g. | 10 |
| Patient helpers, for short | 26 |
| OR pros | 7 |
| Ones who know a lot about anat. | 31 |
| OBs, for example | 16 |