| Orson Scott Card's "___ Game" | 43 |
| Nobelist in Physiology or Medicine: 1954 | 40 |
| Nobelist in medicine, 1954 | 26 |
| Nobelist for Medicine: 1954 | 27 |
| Medical Nobelist in 1954 | 24 |
| Bitter-___ (persistent folks) | 29 |
| "___ Game" | 20 |
| Chess finale | 12 |
| Final stage of a chess match | 28 |
| Beckett play | 12 |
| Chess closing | 13 |
| Board finish | 12 |
| Mating preceder? | 16 |
| Late stages | 11 |
| Last stage of strategy, in chess | 32 |
| Final stage, in chess | 21 |
| Final stage in a chess match | 28 |
| Final move | 10 |
| Final chess stage | 17 |
| Chess-match phase | 17 |
| Chess segment with few pieces on the board | 42 |
| Chess match phase | 17 |
| Chess denouement | 16 |
| Chess climax | 12 |
| Check out time? | 15 |
| Area of chess study | 19 |
| Novelist's need | 19 |
| Happy time in many a film | 25 |
| Credits follow it | 17 |
| You may get annoyed if it's given away | 42 |
| Story part | 10 |
| Place for an O. Henry surprise | 30 |
| Part of a whodunit that reveals who done it | 43 |
| O. Henry surprise | 17 |
| Bad thing to give away | 22 |
| Closes | 6 |
| Denouements | 11 |
| Terminations | 12 |
| They may have twists | 20 |
| Nerves and novels have them | 27 |
| Bad things to give away | 23 |
| They're often served up with twists | 39 |
| The movie "Clue" has three of them | 44 |
| The All-American Rejects' are "Happy" | 51 |
| Some games have multiple ones | 29 |
| Some are happy | 14 |
| Many have twists | 16 |
| Codas | 5 |
| "The ___ near!" | 25 |
| "The ___ near" | 24 |
| "The ___ near!" (doomsayer's phrase) | 50 |
| "The __ near!" | 24 |
| The-near link | 13 |
| "The --- near" (doomsayer's sign) | 47 |
| "The --- near!" | 25 |
| "The _____ near" | 26 |
| " . . . but the ___ not yet": Matt. 24:6 | 50 |
| " . . . ___ not yet": Matt. 24:6 | 42 |
| 'The -- near!' | 22 |
| Break up | 8 |
| Send a Dear John letter | 23 |
| Call the whole thing off | 24 |
| Call off the romance | 20 |
| Call off a project | 18 |
| " . . . Time,/Will one day ___": Shak. | 48 |
| Say "Enough!" | 23 |
| Put a stop to, as with a fight | 30 |
| Get divorced | 12 |
| Get a divorce | 13 |
| Call off a romance | 18 |
| Bring a relationship to a close | 31 |
| Break up, informally | 20 |
| Break off a relationship | 24 |
| Advice to a friend in a bad relationship | 40 |
| Write a Dear John letter | 24 |
| Leave your lover | 16 |
| Initiate the break-up | 21 |
| Do oneself in | 13 |
| Dissolve a relationship | 23 |
| Call off the wedding | 20 |
| Call off the relationship | 25 |
| Break up the romance | 20 |
| Break up the relationship | 25 |
| Break off a romance | 19 |
| Advice from a divorce lawyer, perhaps | 37 |
| ___ all (do oneself in) | 23 |
| Salad base | 10 |
| Salad vegetable, perhaps | 24 |
| Salad bar item | 14 |
| Salad tidbit | 12 |
| Witloof | 7 |
| White-leaved vegetable | 22 |
| Mixed greens green | 18 |
| Leaf that may be used as a bed | 30 |
| Frisée, e.g. | 15 |
| Escarole alternative | 20 |
| Curly-edged salad leaves | 24 |
| Curly salad green | 17 |
| Chicory escarole | 16 |
| Bitter salad veggie | 19 |