| Cold-blooded dice roll? | 23 |
| Cast of two | 11 |
| 2 in craps | 11 |
| 1 + 1 | 5 |
| [.] [.] | 7 |
| Voodoo deity, perhaps | 21 |
| Voodoo deity | 12 |
| Forget-me-not | 13 |
| MONGOOSE? | 9 |
| ___ the grass | 13 |
| Hidden enemy | 12 |
| Traitorous friend | 17 |
| Slyboots? | 9 |
| No true friend | 14 |
| Lurking enemy | 13 |
| Lowdown dirty backstabber | 25 |
| Friend who can't be trusted | 31 |
| Field sight | 11 |
| Creepy character | 16 |
| Two, in a way | 13 |
| Belt material, perhaps | 22 |
| Elixir from a quack | 19 |
| Traveling medicine show purchase | 32 |
| Dubious remedy | 14 |
| Baloney curing product? | 23 |
| Medicine show cure-all | 22 |
| Flim-flam artist | 16 |
| Windshield viper? | 17 |
| Trouble spot for Indiana Jones | 30 |
| Vile place | 10 |
| Stressfully chaotic place | 25 |
| Scene of horror and confusion | 29 |
| Place to keep moccasins | 23 |
| Place of chaotic disorder | 25 |
| Hostile environment | 19 |
| Window-garden choice | 20 |
| Nursery worker's suggestion for a backstabber? | 50 |
| Drain cleaner, at times | 23 |
| It starts in Yellowstone National Park | 38 |
| It runs through southern Idaho | 30 |
| Columbia tributary that forms part of the Idaho-Oregon border | 61 |
| Carver of Hells Canyon | 22 |
| Reputed rattler bite remedy [2001] | 34 |
| Kraits and boas | 15 |
| Twists and turns | 16 |
| They have sliding scales | 24 |
| Racers and rattlers | 19 |
| Hair of Medusa | 14 |
| First word of an Indiana Jones complaint | 40 |
| Critters that Indiana Jones hated | 33 |
| Creatures forming the hair of Medusa | 36 |
| "___ on a Plane" | 26 |
| Treacherous types | 17 |
| Some of them rattle | 19 |
| Some are racers | 15 |
| Slithering hissers | 18 |
| Plumbing tools | 14 |
| Plumbers' helpers | 21 |
| Plumbers' drain openers | 27 |
| Plumbers' cables | 20 |
| Plumber's tools | 19 |
| Pit dwellers | 12 |
| Ophiologist's study | 23 |
| Moccasins and racers | 20 |
| Medusa's hair | 17 |
| Krait and fer-de-lance | 22 |
| Indiana's fear | 18 |
| Caduceus creatures | 18 |
| Bushmaster and mamba | 20 |
| Black Crowes "Three ___ and One Charm" | 48 |
| Adders, etc. | 12 |
| '-- on a Plane' | 23 |
| Where "Hissing 101" is offered? | 41 |
| Reptilian leathers | 18 |
| Pricey partition? | 17 |
| '89 Nazareth album | 22 |
| Chiller about glass-climbing reptiles? | 38 |
| Much-hyped movie of 2006 | 24 |
| Cult classic whose title is depicted four times in this puzzle | 62 |
| 2006 film with the tagline "Sit back, relax, and enjoy the fright" | 76 |
| 2006 film that was an Internet phemonenon before it was released | 64 |
| Toxicology topic | 16 |
| More like a mountain road | 25 |
| With more curves | 16 |
| More winding, as a path | 23 |
| More treacherous | 16 |
| Most sinuous | 12 |
| How some roads ascend a mountain | 32 |
| How some rivers proceed | 23 |
| Plumber's work, at times | 28 |
| Drano alternative? | 18 |
| Dragging lengthwise | 19 |
| Twisting | 8 |
| Twisting and turning | 20 |
| Viperlike | 9 |
| Serpentine or twisty | 20 |
| Sly or sinuous | 14 |
| Sinuate | 7 |
| Like the Gorgons' hair | 26 |
| In coils | 8 |