| Controversial education subject | 31 |
| Chromosome factor | 17 |
| Application line | 16 |
| Application form box | 20 |
| Application check box | 21 |
| Alfred Kinsey research topic | 28 |
| Advertisers say it sells | 24 |
| 1992 Madonna book released in Mylar | 35 |
| ___ appeal | 10 |
| X-movie ingredient | 18 |
| Word with safe or fair | 22 |
| Word with play or act | 21 |
| Word with life and change | 25 |
| Word with fair or safe | 22 |
| Word with appeal or change | 26 |
| Word next to M or F | 19 |
| Word after fair or opposite | 27 |
| What X and Y chromosomes determine | 34 |
| What F or M may indicate | 24 |
| What F or M may denote | 22 |
| What an "M" might indicate | 36 |
| What an "F" might indicate | 36 |
| What an "F" may indicate | 34 |
| We, as a species, have to have it [Ink Well ends June 25 - sign up at avxwords.com to keep getting great indie xwords!] | 119 |
| VI | 2 |
| Union known for its health benefits? | 36 |
| Type of tape or kitten | 22 |
| Type of education | 17 |
| Topic that makes some blush | 27 |
| Topic of "The Hite Report" | 36 |
| Topic for Dr. Ruth | 18 |
| Topic for Carrie Bradshaw | 25 |
| Time to come together? | 22 |
| Time of coming together, perhaps | 32 |
| They say it sells (we'll see how this puzzle does) | 54 |
| The act | 7 |
| Tell the difference in the field | 32 |
| Talk show topic | 15 |
| Taboo topic, sometimes | 22 |
| Survey item | 11 |
| Survey checkoff | 15 |
| Survey check-off | 16 |
| Survey check box | 16 |
| Super seller, supposedly | 24 |
| Subject of much magazine advice | 31 |
| Subject of many a political scandal | 35 |
| Subject of a Manhattan museum near Madison Square Park whose entrance door handles are shaped like the letter X | 111 |
| Subject for Dr. Ruth | 20 |
| Staple of advertising | 21 |
| Source of an androgyne's confusion | 38 |
| Simone de Beauvoir's "The Second ___" | 51 |
| Safe follower | 13 |
| Rolling Stones "___ Drive" | 36 |
| Reason for some political scandals | 34 |
| Reason for an X rating | 22 |
| Rare first-date activity | 24 |
| R cause, often | 14 |
| Quinque +1 | 10 |
| Question, part 4 | 16 |
| Question answered by ''M'' or ''F'' | 67 |
| Perennial talk show topic | 25 |
| Opposite ___ | 12 |
| Opposite __ | 11 |
| One way to catch crabs | 22 |
| One is called fair | 18 |
| Obsession of X-rated films | 26 |
| Object of some drives | 21 |
| Number between quinque and septem | 33 |
| Masters focus | 13 |
| Masters and Johnson subject | 27 |
| Master-Johnson subject | 22 |
| Marcy Playground: "___ and Candy" | 43 |
| Manhattan museum topic | 22 |
| Male, e.g. | 10 |
| Make more alluring, with "up" | 39 |
| Madonna book | 12 |
| Lovin' | 10 |
| Latin 6 | 7 |
| Kitten kind | 11 |
| Kind of scene in a movie | 24 |
| Kind of roles | 13 |
| Kind of pot? | 12 |
| James Brown hit "___ Machine" | 39 |
| It's what made you you | 26 |
| It takes two, usually, at least | 31 |
| It separates the girls from the boys | 36 |
| It sells, reportedly | 20 |
| It sells, it's said | 23 |
| It sells, apparently | 20 |
| It sells in advertising, they say | 33 |
| It requires you to choose a position | 36 |
| It often involves insertion | 27 |
| Increase the appeal of, with "up" | 43 |
| ID information | 14 |
| Group activity, at times | 24 |
| Genophobe's fear | 20 |
| Film-rater's concern | 24 |
| Female, e.g. | 12 |
| F on a questionnaire, e.g. | 26 |
| Dr. Ruth's specialty | 24 |