| ... in "The Man With the Twisted Lip" ... | 51 |
| Turn-of-the-century place to get high | 37 |
| Site of Eastern iniquity | 24 |
| Setting in Sherlock Holmes's "The Man with the Twisted Lip" | 73 |
| Poppy parlor | 12 |
| Old-time drug hangout | 21 |
| Hangout with hookahs | 20 |
| High places? | 12 |
| Measure of neighborhood drug traffic? | 37 |
| What desperate druggie crossword puzzle makers will use as inspiration? | 71 |
| Plant that's a drug source [right hand] | 43 |
| Drug source [right only] | 24 |
| Things that lead to a false sense of contentment | 48 |
| One of two fought between the U.K. and China | 44 |
| Old Britain-China conflict | 26 |
| Qing dynasty conflicts | 22 |
| What some of the letters in this puzzle seemingly have | 54 |
| Surgeon's forte: Abbr. | 26 |
| "Another ___, Another Show" ("Kiss Me, Kate" song) | 70 |
| City on the Odra | 16 |
| Polish province | 15 |
| City in Walesa's land | 25 |
| Knock-off board game suffix found after "Dino," "Dog," or "Ocean" | 95 |
| Suffix for board game spinoffs | 30 |
| Make-Your-Own-___ (customizable board game) | 43 |
| Cockney's invitation to climb aboard | 40 |
| City north of Lisbon | 20 |
| Iberian wine city | 17 |
| Wine city north of Lisbon | 25 |
| Portugal's second-largest city | 34 |
| City on the Douro | 17 |
| Portuguese wine city | 20 |
| Portuguese harbor on the Douro | 30 |
| Portuguese harbor | 17 |
| Portugal's second-biggest city | 34 |
| Port of Portugal | 16 |
| Iberian port | 12 |
| Iberian city that lends its name to a variety of wine | 53 |
| Henry the Navigator's birthplace | 36 |
| City north of Lisbon, Portugal | 30 |
| City famous for a sweet wine | 28 |
| City captured by the Moors in the 8th century | 45 |
| City about 175 miles north of Lisbon | 36 |
| City 175 miles north of Lisbon | 30 |
| Universal donor's blood type | 32 |
| Common bank deposit? | 20 |
| Bank deposit, often | 19 |
| Czech stream: Ger. spelling | 27 |
| Controversial physicist | 23 |
| Happy Hooligan's creator | 28 |
| "Happy Hooligan" cartoonist | 37 |
| Cartoonist Frederick | 20 |
| Residents of a town | 19 |
| Schmeling, to Louis | 19 |
| Tilden, to Hayes | 16 |
| One from the other side | 23 |
| Frazier, to Ali | 15 |
| Ali, to Frazier at Manila | 25 |
| Best time to act | 16 |
| Knock heeder | 12 |
| Arkansas' tag motto: Land of ____ | 37 |
| Microeconomics concept | 22 |
| Job listing at a noted fort? | 28 |
| Thumblike | 9 |
| Subject to being challenged | 27 |
| Open to contravention | 21 |
| Human hand characteristic | 25 |
| Feature of opossums' hind feet | 34 |
| Contested | 9 |
| Saying 'nay' | 20 |
| Offered resistance | 18 |
| Like cons | 9 |
| Competed against | 16 |
| Was hostile to | 14 |
| Spoke out against | 17 |
| Ran against | 11 |
| Like a naysayer | 15 |
| Fought against | 14 |
| Takes the anti side | 19 |
| Takes a stand against | 21 |
| Stands against | 14 |
| Sets against | 12 |
| Runs against | 12 |
| Resists | 7 |
| Fighting back | 13 |
| Element of irony | 16 |
| O'er | 8 |
| To and fro, for example | 23 |
| They attract | 12 |
| Night and day, say | 18 |
| Completely different pair | 25 |
| Birds of a feather flock together, but ... | 42 |
| Jane, to Dick, e.g. | 19 |
| Other direction | 15 |
| Puts under the yoke | 19 |
| Weighing down Top 40 artists? | 29 |
| The mighty to the meek, historically | 36 |
| White Russian, to Lenin | 23 |
| Unfair or cruel leader | 22 |
| Controverts | 11 |