| Alcohol misuser | 15 |
| Home of the storied Mouse Tower | 31 |
| Problem drinker | 15 |
| One given to sprees on horseback? | 33 |
| Not be a show-stopper? | 22 |
| Dark red cherries? | 18 |
| "Fur Traders Descending the Missouri" painter, 1845 | 61 |
| It's adjacent to St. James's Park | 41 |
| Crosby nickname, with "Der" | 37 |
| Base hits | 9 |
| Item where the middle is automatically marked | 45 |
| Game accessory with 24 numbered squares | 39 |
| Gambling singer? | 16 |
| Someone might call your number this evening | 43 |
| Where granny goes on Friday nights, stereotypically | 51 |
| Numbers game locale | 19 |
| Places where you can hear "B4" called out | 51 |
| Gambler who needs five in a row | 31 |
| Some cherries | 13 |
| Dark red cherries | 17 |
| Crosby namesakes | 16 |
| Ex-hoopster Dave, after he went to Washington? | 46 |
| Study of a crooner's lyrics? | 32 |
| Vietnam's ___ Dinh | 22 |
| Binh ___, Vietnam | 17 |
| "I Puritani," for one | 31 |
| Put in storage, like coal | 25 |
| Prince Edward Island Premier, Pat | 33 |
| 30th Prince Edward Island Premier | 33 |
| Card game akin to bezique | 25 |
| Like some vision | 16 |
| Like human vision | 17 |
| Opera glasses, e.g. | 19 |
| Need them for nosebleed seats | 29 |
| Bird-watcher's need | 23 |
| Bird watcher's accessory | 28 |
| Vision "pair"/clothing "pair" | 49 |
| Cyclops's lack | 18 |
| Aid in judging distances | 24 |
| Kind of theorem | 15 |
| Consisting of two terms | 23 |
| Certain theorem in math | 23 |
| Algebraic formula discovered by Omar Khayyám | 47 |
| Trashy musicians? | 17 |
| Extremely exasperated | 21 |
| Science specialty | 17 |
| Asimov, per his doctorate | 25 |
| Personal information, literally | 31 |
| Some resume info | 16 |
| Marketer's accumulation | 27 |
| Info about a person's education and work history | 52 |
| Details about one's life and job | 36 |
| Capable of being decomposed | 27 |
| Capable of decaying | 19 |
| Enclosed ecosystem | 18 |
| Montreal eco-tourist attraction | 31 |
| Ecosystem-replicating facility | 30 |
| Closed ecosystems | 17 |
| It can be made with sugar cane or corn | 38 |
| Gas from beans, e.g. | 20 |
| Ethanol, for one | 16 |
| Renewable fuel on some farms | 28 |
| Result of some fermentation | 27 |
| Renewable fuel derived from organic matter | 42 |
| Fuel derived from fermenting organic waste | 42 |
| Hypothetical protein molecule | 29 |
| Hypothetical cell unit | 22 |
| Like Ernst Haeckel's law | 28 |
| Controversial engineering | 25 |
| LIFELINE | 8 |
| Some writers | 12 |
| Artificial tissue generation materials | 38 |
| Pertaining to the science of life | 33 |
| Natural medical product, such as serum | 38 |
| Of life | 7 |
| Jet lag monitor, in a way | 25 |
| Natural timekeeper, of a sort | 29 |
| Controller of life cycles | 25 |
| Watch come to life? | 19 |
| Watson and Crick, for two | 25 |
| Julian Huxley and James Watson | 30 |
| Body work? | 10 |
| What John Scopes taught | 23 |
| Study of life | 13 |
| Dissection class | 16 |
| Cutting class? | 14 |
| Natural glow? | 13 |
| Renewable energy source | 23 |
| Plant material used for fuel | 28 |
| Organic matter used for fuel | 28 |
| Living matter in total | 23 |
| All organisms in one area, collectively | 39 |
| Large ecosystems | 16 |
| Ecological communities | 22 |
| Some complex communities | 24 |
| Rain forests and grasslands, e.g. | 33 |
| Ecologists' study | 21 |
| Ecological units | 16 |
| Carbon dioxide measurer | 23 |
| Device that measures emanations of carbon dioxide | 49 |