| First Arab country to have sanctions imposed on it by the Arab League | 69 |
| First Arabic letter | 19 |
| First arboretum | 15 |
| First area to fill in on a form | 31 |
| First Army first name | 21 |
| First arrival | 13 |
| First Arthur C. Clarke Award winner | 35 |
| First artificial satellite | 26 |
| First Asian city to host the Winter Olympics | 44 |
| First Asian country to rule in favor of same-sex marriage | 57 |
| First Asian-American Cabinet member | 35 |
| First aspirin maker | 19 |
| First assembly-line carmaker | 28 |
| First asteroid | 14 |
| First asteroid discovered | 25 |
| First asteroid ever discovered | 30 |
| First asteroid landed on by a NASA craft | 40 |
| First asteroid landed on by a spacecraft | 40 |
| First asteroid orbited by a NASA spacecraft | 43 |
| First athlete to appear on the cover of Time magazine | 53 |
| First athlete to lend his name to a video game | 46 |
| First attempt | 13 |
| First attempts? | 15 |
| First author of the "Oz" books | 40 |
| First authority | 15 |
| First auto to offer seat belts | 30 |
| First baby picture, often | 25 |
| First baby picture, perhaps | 27 |
| First ballplayer to hit 50 home runs before the end of August | 61 |
| First band, alphabetically, on many an iPod | 43 |
| First base man? | 15 |
| First base? | 11 |
| First baseball commissioner | 27 |
| First baseball czar | 19 |
| First baseball Hall of Famer | 28 |
| First Baseball Hall-of-Famer, alphabetically | 44 |
| First baseball player involved in an instant replay decision | 60 |
| First baseball player to have his number retired | 48 |
| First baseball player to make $1 million a year | 47 |
| First baseball team to play in a dome | 37 |
| First baseball team to use batting helmets | 42 |
| First baseballer? | 17 |
| FIRST BASEMAN | 13 |
| First baseman and ss. | 21 |
| First baseman Brogna | 20 |
| First baseman in a classic comedy sketch | 40 |
| First baseman in a famous comedy routine | 40 |
| First baseman Martinez | 22 |
| First baseman Mientkiewicz who caught the final out of the 2004 Boston World Series victory | 91 |
| First baseman of comedy | 23 |
| First baseman Palmeiro | 22 |
| First baseman Palmeiro who was suspended for using steroids | 59 |
| First baseman Palmiero | 22 |
| First baseman Vaughn's book about bad pitching? | 51 |
| First baseman's glove | 25 |
| First baseman, to Abbott and Costello | 37 |
| First batter to hit a home run against every Major League Baseball team | 71 |
| First battery brand to feature an indefatigable pink bunny in its ads | 69 |
| First battle of Revolution | 26 |
| First battle site of the Hundred Years War (1346) | 49 |
| First bear to detect Goldilocks's intrusion | 47 |
| First bed | 9 |
| First bedroom sharer, for short | 31 |
| First beer container for the gang? | 34 |
| First Best Actor Oscar winner Jannings | 38 |
| First Best Actor Oscar winner, ___ Jannings | 43 |
| First Best Actor winner Jannings | 32 |
| First Best Actress Oscar winner | 31 |
| First Best Actress winner | 25 |
| First Bible bk. | 15 |
| First Bible book | 16 |
| First Biblical casualty | 23 |
| First Biblical grandson | 23 |
| First bidder | 12 |
| First bidder in bridge games | 28 |
| First bidder, at bridge | 23 |
| First billionaire book author | 29 |
| First Billy Bigelow in ''Carousel'' | 51 |
| First bird off the Ark, in Genesis | 34 |
| First birthday suit? | 20 |
| First bishop of Crete, traditionally | 36 |
| First bishop of Paris | 21 |
| First bishop of Rome | 20 |
| First bit of solid food for many a baby | 39 |
| First biter | 11 |
| First bk. | 9 |
| First black American Leaguer Larry | 34 |
| First black billionaire | 23 |
| First black congresswoman Shirley | 33 |
| First black female senator Moseley Braun | 40 |
| First black major-league baseball coach Buck ___ | 48 |
| First black N.F.L. Hall-of-Famer ___ Tunnell | 44 |
| First black player on the US Davis Cup team | 43 |
| First black poet to win a Pulitzer Prize | 40 |
| First Black Sabbath album w/Dio | 31 |
| First black woman elected to Congress | 37 |
| First blond Bond | 16 |
| First Bond actor born after the Bond films began | 48 |
| First Bond film | 15 |
| First Bond flick | 16 |