| Opry star with a price on her head? | 35 |
| Opt for a career without the band | 33 |
| Opt for the window instead of the aisle? | 40 |
| Opt not to be a state of the Union | 34 |
| Optical body used to disperse light | 35 |
| Optical instrument pointed at a moon of Saturn? | 47 |
| Optical tool for a computer user | 32 |
| Optimal design for clinical trials | 34 |
| Optimist's "attitude" | 35 |
| Optimistic investors at the Panthers' school? | 49 |
| Optimistic scan at the dentist's? | 37 |
| Optimus and Xpression smartphones, e.g. | 39 |
| Option after a transmission failure | 35 |
| Option at a butcher's, maybe | 32 |
| Option at a fast-food restaurant | 32 |
| Option for "Which came first ...?" | 44 |
| Option for a traveling politician | 33 |
| Option for an int'l visa student | 36 |
| Option for first-time offenders? | 32 |
| Option for preparing eggs, briefly? | 35 |
| Option for seeing the sites quickly, for short | 46 |
| Option not available in a convertible | 37 |
| Option on "Let's Make a Deal" | 43 |
| Option on "Wheel of Fortune" | 38 |
| Option under "employer" on forms | 42 |
| Option while waiting for Mr. Right? | 35 |
| Optional section on some applications | 37 |
| Optional's meaning, in car pricing | 38 |
| Options above "all of the above" | 42 |
| Options above "none of the above" | 43 |
| Options for changing the inhabitants? | 37 |
| Options for salting away, briefly | 33 |
| Options for tackling very dirty dishes | 38 |
| Options for those dealing with personal demons? | 47 |
| Options in a primitive stress response | 38 |
| OPTOMETRIST chauffeurs poodles and Persians? | 44 |
| Optometrist Stanley who founded a store chain | 45 |
| Optometrist's cherished alma mater? | 39 |
| Optometrist's concern: Abbr. | 32 |
| Opus choreographed by Balanchine | 32 |
| Opus that opened at a hall in Memphis | 37 |
| Opus __: "The Da Vinci Code" sect | 43 |
| Opus ___ ("The Da Vinci Code" group) | 46 |
| Opus ___ ("The Da Vinci Code" sect) | 45 |
| Or's correlative, in Yorkshire | 34 |
| Oral polio vaccine pioneer Albert | 33 |
| Orally take huge amounts of salt water (4) | 42 |
| Orange 'Sesame Street' Muppet | 37 |
| Orange "Sesame Street" denizen | 40 |
| Orange "Sesame Street" Muppet | 39 |
| Orange and blue wearer, for short | 33 |
| Orange circular button in SoundCloud | 36 |
| Orange County's area, slangily | 34 |
| Orange item set out by a highway crew | 37 |
| Orange leftover eaten on Black Friday | 37 |
| Orange monster on "Sesame Street" | 43 |
| Orange Muppet voiced by Fran Brill | 34 |
| Orange Pekoe or English Breakfast | 33 |
| Orange Place on a Monopoly board | 32 |
| Orange shade named for a painter | 32 |
| Orange square with Tennessee and New York | 41 |
| Orange tea that's really black | 34 |
| Orange tree oil used in perfumes | 32 |
| Orange ___ (tea that is, ironically, black) | 43 |
| Orange, peach or strawberry product | 35 |
| Orange, tangerine, and grapefruit hybrid | 40 |
| Orange-and-black perennial [2010] | 33 |
| Orange-and-black-winged butterflies | 35 |
| Orange-nosed Sesame Street resident | 35 |
| Orange-roofed eateries, for short | 33 |
| Orange-roofed establishment, in brief | 37 |
| Orange-roofed restaurant, familiarly | 36 |
| Orange-to-red star, as Aldebaran | 32 |
| Oranges' neighbors on spectrum | 34 |
| Oranges, reds and golds, in fashion terms | 41 |
| Orator's improvised platform | 32 |
| Oratorio with the "Hallelujah" chorus | 47 |
| Orb's partner, in British iconography | 41 |
| Orbison of the Traveling Wilburys | 33 |
| Orbison who sang "Oh, Pretty Woman" | 45 |
| Orbital point farthest from Earth | 33 |
| Orbital point farthest from the sun | 35 |
| Orbital points farthest from Earth | 34 |
| Orbital position nearest the sun | 32 |
| Orbital station that broke up in 2001 | 37 |
| Orchard man's street in Atlanta? | 36 |
| Orchestra conductor's outfit | 32 |
| Orchestra leader born July 4, 1911 | 34 |
| Orchestra that plays light classical music | 42 |
| Orchestra's "tuning fork" | 39 |
| Orchestra's "tuning" instrument | 45 |
| Orchestra's funding org., perhaps | 37 |
| Orchestra's percussion or strings, e.g. | 43 |
| Orchestra's place on Broadway | 33 |
| Orchestra's place, sometimes | 32 |
| Orchestra's tuning instrument | 33 |
| Orchestral "tuning fork" | 34 |
| Orchestral composition based on literature | 42 |
| Orchestral composition by Claude Debussy | 40 |
| Orchestral fairy tale by Prokofiev | 34 |