| First Canadian to run the mile in under 4 minutes | 49 |
| First Canadian Olympic gold medalist | 36 |
| First Canadian city to host the Winter Olympics | 47 |
| First British settlement in India | 33 |
| First brewery to put beer in cans | 33 |
| First book of the Bible, alphabetically | 39 |
| First book of the 12 Minor Prophets | 35 |
| First book of el Nuevo Testamento | 33 |
| First Bond actor born after the Bond films began | 48 |
| First black woman elected to Congress | 37 |
| First black poet to win a Pulitzer Prize | 40 |
| First black player on the US Davis Cup team | 43 |
| First black N.F.L. Hall-of-Famer ___ Tunnell | 44 |
| First black major-league baseball coach Buck ___ | 48 |
| First black female senator Moseley Braun | 40 |
| First black congresswoman Shirley | 33 |
| First black American Leaguer Larry | 34 |
| First bit of solid food for many a baby | 39 |
| First bishop of Crete, traditionally | 36 |
| First bird off the Ark, in Genesis | 34 |
| First Best Actor winner Jannings | 32 |
| First Best Actor Oscar winner, ___ Jannings | 43 |
| First Best Actor Oscar winner Jannings | 38 |
| First beer container for the gang? | 34 |
| First bear to detect Goldilocks's intrusion | 47 |
| First battle site of the Hundred Years War (1346) | 49 |
| First baseman, to Abbott and Costello | 37 |
| First baseman in a famous comedy routine | 40 |
| First baseman in a classic comedy sketch | 40 |
| First baseball team to use batting helmets | 42 |
| First baseball team to play in a dome | 37 |
| First baseball player to make $1 million a year | 47 |
| First baseball player to have his number retired | 48 |
| First Baseball Hall-of-Famer, alphabetically | 44 |
| First band, alphabetically, on many an iPod | 43 |
| First author of the "Oz" books | 40 |
| First athlete to lend his name to a video game | 46 |
| First asteroid orbited by a NASA spacecraft | 43 |
| First asteroid landed on by a spacecraft | 40 |
| First asteroid landed on by a NASA craft | 40 |
| First Asian-American Cabinet member | 35 |
| First Asian city to host the Winter Olympics | 44 |
| First Arthur C. Clarke Award winner | 35 |
| First application line to fill in | 33 |
| First appearance, as of symptoms | 32 |
| First Annual Grammy Awards host Mort | 36 |
| First animal in the Chinese zodiac | 34 |
| First and Second Avenues area, in Manhattan | 43 |
| First and last word of the Musketeers' motto | 48 |
| First and last word of a W. S. title | 36 |
| First and last name of an author | 32 |
| First and last digit in a Manhattan area code | 45 |
| First American Tour de France winner Greg | 41 |
| First American to win the Tour de France | 40 |
| First American to orbit the Earth | 33 |
| First American Red Cross president Barton | 41 |
| First American Railway Union president | 38 |
| First American movie to show a toilet flushing | 46 |
| First American minister to England | 34 |
| First American literature Nobelist | 34 |
| First American executed for spying | 34 |
| First Amendment lobbyists, for short | 36 |
| First Amendment defender, for short | 35 |
| First all-purpose digital computer | 34 |
| First album in a Green Day trilogy | 34 |
| First airline with a transpolar route | 37 |
| First airline to operate a transpolar route | 43 |
| First aid administrant on a battlefield | 39 |
| First African-born Literature Nobelist | 38 |
| First African-American US Open champ | 36 |
| First African-American to play at the Masters | 45 |
| First African-American secretary of state | 41 |
| First African-American on a US stamp | 36 |
| First African-American major-league coach Buck | 46 |
| First African-American major-league coach | 41 |
| First African-American major-league catcher | 43 |
| First AFL team to beat an NFL team | 34 |
| First actor to turn down an Academy Award | 41 |
| First "Today" host Dave | 33 |
| First "Sunday Morning" host | 37 |
| First "Match Game" announcer | 38 |
| First "Idol" winner Clarkson | 38 |
| First "Family Feud" host | 34 |
| First "Commander of the Faithful" | 43 |
| First "Come on down!" announcer | 41 |
| First "Blue's Clues" host | 39 |
| First "Bachelorette" Trista | 37 |
| First "American Idol" winner Clarkson | 47 |
| First ''Time'' publisher | 40 |
| First ''L'' of L.L. Bean | 40 |
| First ''A'' of A.A. Milne | 41 |
| Firm negotiating stances: 2 wds. | 32 |
| Firm commitment made by the press? | 34 |
| Firm bigwig, in a first language? | 33 |
| Firm belief, either way you look at it | 38 |
| Fireworks, air shows, glasses, etc. | 35 |
| Fireworks watcher's exclamation | 35 |
| Fireworks time, with "the" | 36 |
| Fireworks that shoot "stars" | 38 |
| Fireside song from "The Penguins"? | 44 |