| First African-American US Open champ | 36 |
| First African-born Literature Nobelist | 38 |
| First aid administrant on a battlefield | 39 |
| First airline to operate a transpolar route | 43 |
| First airline with a transpolar route | 37 |
| First album in a Green Day trilogy | 34 |
| First all-purpose digital computer | 34 |
| First Amendment defender, for short | 35 |
| First Amendment lobbyists, for short | 36 |
| First American executed for spying | 34 |
| First American literature Nobelist | 34 |
| First American minister to England | 34 |
| First American movie to show a toilet flushing | 46 |
| First American Railway Union president | 38 |
| First American Red Cross president Barton | 41 |
| First American to orbit the Earth | 33 |
| First American to win the Tour de France | 40 |
| First American Tour de France winner Greg | 41 |
| First and last digit in a Manhattan area code | 45 |
| First and last name of an author | 32 |
| First and last word of a W. S. title | 36 |
| First and last word of the Musketeers' motto | 48 |
| First and Second Avenues area, in Manhattan | 43 |
| First animal in the Chinese zodiac | 34 |
| First Annual Grammy Awards host Mort | 36 |
| First appearance, as of symptoms | 32 |
| First application line to fill in | 33 |
| First Arthur C. Clarke Award winner | 35 |
| First Asian city to host the Winter Olympics | 44 |
| First Asian-American Cabinet member | 35 |
| First asteroid landed on by a NASA craft | 40 |
| First asteroid landed on by a spacecraft | 40 |
| First asteroid orbited by a NASA spacecraft | 43 |
| First athlete to lend his name to a video game | 46 |
| First author of the "Oz" books | 40 |
| First band, alphabetically, on many an iPod | 43 |
| First Baseball Hall-of-Famer, alphabetically | 44 |
| First baseball player to have his number retired | 48 |
| First baseball player to make $1 million a year | 47 |
| First baseball team to play in a dome | 37 |
| First baseball team to use batting helmets | 42 |
| First baseman in a classic comedy sketch | 40 |
| First baseman in a famous comedy routine | 40 |
| First baseman, to Abbott and Costello | 37 |
| First battle site of the Hundred Years War (1346) | 49 |
| First bear to detect Goldilocks's intrusion | 47 |
| First beer container for the gang? | 34 |
| First Best Actor Oscar winner Jannings | 38 |
| First Best Actor Oscar winner, ___ Jannings | 43 |
| First Best Actor winner Jannings | 32 |
| First bird off the Ark, in Genesis | 34 |
| First bishop of Crete, traditionally | 36 |
| First bit of solid food for many a baby | 39 |
| First black American Leaguer Larry | 34 |
| First black congresswoman Shirley | 33 |
| First black female senator Moseley Braun | 40 |
| First black major-league baseball coach Buck ___ | 48 |
| First black N.F.L. Hall-of-Famer ___ Tunnell | 44 |
| First black player on the US Davis Cup team | 43 |
| First black poet to win a Pulitzer Prize | 40 |
| First black woman elected to Congress | 37 |
| First Bond actor born after the Bond films began | 48 |
| First book of el Nuevo Testamento | 33 |
| First book of the 12 Minor Prophets | 35 |
| First book of the Bible, alphabetically | 39 |
| First brewery to put beer in cans | 33 |
| First British settlement in India | 33 |
| First Canadian city to host the Winter Olympics | 47 |
| First Canadian Olympic gold medalist | 36 |
| First Canadian to run the mile in under 4 minutes | 49 |
| First Canadian winner at Augusta | 32 |
| First Canadian woman atop Everest | 33 |
| First Canadian-born Governor General | 36 |
| First canonized native-born American | 36 |
| First capital of the kingdom of Italy | 37 |
| First capital of the Last Frontier | 34 |
| First card played in the game parliament | 40 |
| First card turned up in a game of faro | 38 |
| First Catholic vice president of the U.S. | 41 |
| First celebrity on "Sesame Street" | 44 |
| First chancellor of West Germany | 32 |
| First character seen in "Zelig" | 41 |
| First character to appear in "Carmen" | 47 |
| First Chief Justice of the United States | 40 |
| First chronicled Chinese dynasty | 32 |
| First cigarette brand to introduce filters | 42 |
| First CinemaScope film (With "The") | 45 |
| First circle on a Scantron sheet, often | 39 |
| First city bombed in W.W. II's Baedeker Blitz | 49 |
| First class, briefly, for some kids | 35 |
| First comes love, then comes these three | 40 |
| First comes love, then comes these two | 38 |
| First comes love, then these four | 33 |
| First comes love, then these three | 34 |
| First coml. airline to show in-flight movies | 44 |
| First comment from a certain doctor? | 36 |
| First commercial carrier to use the Boeing 747 | 46 |
| First commercially successful computer | 38 |
| First company to sell soft contact lenses | 41 |
| First compass point, alphabetically | 35 |