| XLIII years from the publication of this puzzle | 47 |
| X-___ (villains in the video game Paper Mario) | 46 |
| X-shaped warning sign next to railroad tracks | 45 |
| X-Wife song from "Rockin' Rio" | 44 |
| XII years after Columbus's famous voyage | 44 |
| XM shock jock Gregg Hughes's on-air name | 44 |
| Xhosa and Zulu are among its official langs. | 44 |
| XII years after Columbus's first voyage | 43 |
| XII years before the Battle of Hastings | 39 |
| X-rated editions of Garfield and Ziggy? | 39 |
| XV years before the Battle of Hastings | 38 |
| XI years before the Battle of Hastings | 38 |
| X, in the Neighborhood of Make-Believe | 38 |
| Xena and Charon, as of August 16, 2006 | 38 |
| X-ray machine's successor (Abbr.) | 37 |
| Xylem conducts them upward from roots | 37 |
| Xenon, for example, in the atmosphere | 37 |
| XTC "The ___ of Simpleton" | 36 |
| X-ray vision can't penetrate it | 35 |
| X'd, as a candidate's name | 34 |
| Xanthippe's philosophical mate | 34 |
| X-___ (large, in commercial names) | 34 |
| X-Men enemy who can control fire | 32 |
| X-___ (big, in commercial names) | 32 |