| Mr. Rebozo | 10 |
| Mr. Redding after making it big? | 32 |
| Mr. Reliable-in-a-crisis | 24 |
| Mr. Renee Zellweger, for 225 days | 33 |
| Mr. Republican | 14 |
| Mr. Rhodes of Rhodes scholarships | 33 |
| Mr. Rhodes of Rhodesia | 22 |
| Mr. Right | 9 |
| Mr. Right, e.g. | 15 |
| Mr. Right, hopefully | 20 |
| Mr. Right, say | 14 |
| Mr. Right, with "the" | 31 |
| Mr. Ripken | 10 |
| Mr. Robbins who partnered with Burt Baskin | 42 |
| Mr. Roberts | 11 |
| Mr. Roberts portrayer | 21 |
| Mr. Rochester's ward | 24 |
| Mr. Rogers | 10 |
| Mr. Rogers and others | 21 |
| Mr. Rogers on a horse | 21 |
| Mr. Rogers trademark | 20 |
| Mr. Rogers was a Navy Seal, e.g. | 32 |
| Mr. Rogers was spotted here | 27 |
| Mr. Rogers' first name | 26 |
| Mr. Rogers's zippered sweater | 33 |
| Mr. Root | 8 |
| Mr. Rosewater in Kurt Vonnegut's "God Bless You, Mr. Rosewater" | 77 |
| Mr. Royce's partner | 23 |
| Mr. Rubik | 9 |
| Mr. Rubinstein | 14 |
| Mr. Saarinen | 12 |
| Mr. Sadat | 9 |
| Mr. Sajak | 9 |
| Mr. Sandman's material | 26 |
| Mr. Schindler | 13 |
| Mr. Scissorhands | 16 |
| Mr. Scott | 9 |
| Mr. Scratch | 11 |
| Mr. Scrooge | 11 |
| Mr. Serling | 11 |
| Mr. Shankar | 11 |
| Mr. Sharif | 10 |
| Mr. Sheep | 9 |
| Mr. Shoemaker's goal | 24 |
| Mr. Shostakovich | 16 |
| Mr. Sikorsky | 12 |
| Mr. Simpson | 11 |
| Mr. Six-Pack | 12 |
| Mr. Slate, to Fred Flintstone | 29 |
| Mr. Smith portrayer | 19 |
| Mr. Smith who went to Wash., e.g. | 33 |
| Mr. Smithers, e.g. | 18 |
| Mr. Solo | 8 |
| Mr. Sondheim | 12 |
| Mr. Spacely's first name on "The Jetsons" | 55 |
| Mr. Spassky | 11 |
| Mr. Speaker | 11 |
| Mr. Spielberg | 13 |
| Mr. Spock portrayer | 19 |
| Mr. Spock portrayer Nimoy | 25 |
| Mr. Spock's father in "Star Trek" | 47 |
| Mr. Spock's forte | 21 |
| Mr. Spock's had a point | 27 |
| Mr. Spock's irises? | 23 |
| Mr. Spock's method of reasoning | 35 |
| Mr. Spock's mother | 22 |
| Mr. Spock's pointy pair | 27 |
| Mr. Spock's rank: Abbr. | 27 |
| Mr. Spock's shipmate | 24 |
| Mr. Spock's side arm | 24 |
| Mr. Spock's specialty | 25 |
| Mr. Spock's strong suit | 27 |
| Mr. Spock, notably | 18 |
| Mr. Sprat's fare | 20 |
| Mr. Stallone, to friends | 24 |
| Mr. Standish | 12 |
| Mr. Stohler's job in "Breaking Away" | 50 |
| Mr. Stork's traveling attire? | 33 |
| Mr. Strauss | 11 |
| Mr. Strauss of pants fame | 25 |
| Mr. Stravinsky | 14 |
| Mr. Sulu's portrayer | 24 |
| Mr. Sun | 7 |
| Mr. T and cohorts | 17 |
| Mr. T and pals | 14 |
| Mr. T catch phrase | 18 |
| Mr. T et al. | 12 |
| Mr. T flick | 11 |
| Mr. T group | 11 |
| Mr. T movie | 11 |
| Mr. T played a member of this | 29 |
| Mr. T series, with "The" | 34 |
| Mr. T TV group | 14 |
| Mr. T TV series, with 'The' | 35 |
| Mr. T's "___-Team" | 32 |
| Mr. T's associates | 22 |
| Mr. T's bunch | 17 |
| Mr. T's crew | 16 |
| Mr. T's former group | 24 |
| Mr. T's former TV show, with "The" | 48 |