| Sophia of "Marriage Italian-Style" | 44 |
| Sophie Tucker was the "last" | 38 |
| Sophie's "choice" and others | 42 |
| Sophistic, involved argumentation | 33 |
| Sophisticated attack rocket (abbr.) | 35 |
| Sophisticated detection aircraft | 32 |
| Sophisticated U.S. detection aircraft | 37 |
| Sophisticated, fashionable people | 33 |
| Sophocles drama about archaeological ruins? | 43 |
| Sophomores at a Columbus col., e.g. | 35 |
| Soprano a k a "Bubbles" | 33 |
| Soprano Alda's "Men, Women and ___" | 49 |
| Soprano Cavalieri, a contemporary of Caruso | 43 |
| Soprano in "Die Fledermaus" | 37 |
| Soprano in "One Night of Love" | 40 |
| Soprano in "The Barber of Seville" | 44 |
| Soprano Licia, singer at the Met for 26 years | 45 |
| Soprano Mauti-Nunziata of the Met | 33 |
| Soprano Mitchell and hotelier Helmsley, e.g. | 44 |
| Soprano nicknamed "Bubbles" | 37 |
| Soprano pineapple and others, briefly | 37 |
| Soprano role in "Ariadne auf Naxos" | 45 |
| Soprano role in "Don Giovanni" | 40 |
| Soprano role in "Il Trovatore" | 40 |
| Soprano role in "Orfeo ed Euridice" | 45 |
| Soprano role in "The Barber of Seville" | 49 |
| Soprano role in "The Magic Flute" | 43 |
| Soprano roles in operas by Cherubini and Giordano | 49 |
| Soprano Tetrazzini: 1847–1940 | 36 |
| Soprano who joined the Met in 1974 | 34 |
| Soprano who once worked for P. T. Barnum | 40 |
| Soprano who wrote "My Life" | 37 |
| Soprano who's unlikely to sing? | 35 |
| Soprano's pièce de résistance | 39 |
| Sopranos in operas by Strauss and Massenet | 42 |
| Sorbonne, ''par exemple'' | 41 |
| Sorcerer behind Amin's rise to power? | 41 |
| Sorceress encountered by Odysseus | 33 |
| Sorceress in the "Odyssey" | 36 |
| Sorceress in the Golden Fleece myth | 35 |
| Sorceress on the island of Aeaea | 32 |
| Sorceress who aided Jason's quest | 37 |
| Sorcery practiced in the West Indies | 36 |
| Sore labour's bath, to Shakespeare | 38 |
| Sore loser's reaction, maybe | 32 |
| Sore loser's reaction, sometimes | 36 |
| Sore throat and sneezing, for a cold | 36 |
| Sorely lacking (with "with") | 38 |
| Soreness causes shaggy ox to lose focus? | 40 |
| Soreness from a smoker's cough, to Dr. Dre? | 47 |
| Sorkin of "The West Wing" | 35 |
| Sorkin who created "The West Wing" | 44 |
| Sorkin who wrote "The Social Network" | 47 |
| Sorority founded at Howard University in 1920 | 45 |
| Sorority house denizens, perhaps | 32 |
| Sorority's counterpart, for short | 37 |
| Sorrel of fiction and Green of finance | 38 |
| Sorrow-drowning drug of the ancients | 36 |
| Sort of words that sailors are famous for | 41 |
| Sort who doesn't hang with others | 37 |
| Sort who isn't safe around a safe | 37 |
| Sort who's a natural leader, supposedly | 43 |
| Sorvino in "Mighty Aphrodite" | 39 |
| Sorvino of ''Mighty Aphrodite'' | 47 |
| Sorvino of "Mighty Aphrodite" | 39 |
| Sorvino of "Summer of Sam" | 36 |
| Sot's affliction, with "the" | 42 |
| Sot's withdrawal syndrome, briefly | 38 |
| Sotheby Parke _____ (auction house, formerly) | 45 |
| Sothern belle from North Dakota? | 32 |
| Sotto ___ (under one's breath) | 34 |
| Sought after, with "to" | 33 |
| Sought evidence of counterfeiting? | 34 |
| Sought the opinions of, in a way | 32 |
| Sought-after former football announcer? | 39 |
| Sought-after sign during bad band | 33 |
| Soul Asylum "Can't ___ Tell" | 42 |
| Soul Asylum "Candy ___ Stranger" | 42 |
| Soul Asylum "Easy to ___" | 35 |
| Soul Asylum "Keep ___" | 32 |
| Soul Asylum "Let Your ___ Light Shine" | 48 |
| Soul Asylum "Without a ___" | 37 |
| Soul backing band named for their singer | 40 |
| Soul Coughing album with "Circles" | 44 |
| Soul label with a museum in Memphis | 35 |
| Soul label with a snapping finger logo | 38 |
| Soul of the dead, in Philippine folklore | 40 |
| Soul singer Thomas and food writer Rombauer | 43 |
| Soul singer with a dot in her name | 34 |
| Soul singer with iconic facial scars | 36 |
| Soul-sucking endeavor in a bad economy (CEO) | 44 |
| Soulful "Right as Rain" Brit | 38 |
| Sound --- (short recorded quote) | 32 |
| Sound a person with a crook might hear | 38 |
| Sound accompanying a certain spasm | 34 |
| Sound accompanying a cloud of smoke | 35 |
| Sound accompanying an enraged exit | 34 |
| Sound after a pin prick, perhaps | 32 |
| Sound after a pinprick, sometimes | 33 |
| Sound after littering, sometimes | 32 |