| Smallest of five Greats | 23 |
| Smallest Great Lake in volume | 29 |
| Smallest Great Lake by volume | 29 |
| Site of many eerie mishaps | 26 |
| Site of 1813 naval battle | 25 |
| Shallowest of the Great ones | 28 |
| Scene of Perry's triumph | 28 |
| Scene of Perry's heroism | 28 |
| Sandusky County's lake | 26 |
| Sal the mule's domain | 25 |
| Railroad, lake or canal | 23 |
| Railroad that failed in 1861 | 28 |
| Railroad launched in 1851 | 25 |
| Railroad guided by Jay Gould | 28 |
| Put-in-Bay's place | 22 |
| Put-in-Bay's locale | 23 |
| Port north of Meadville | 23 |
| Perry's victory site | 24 |
| Perry's headquarters | 24 |
| Pennsylvania's lake port | 28 |
| Pennsylvania city or county | 27 |
| Penn State branch site | 22 |
| Part of the HOMES mnemonic | 26 |
| Ontario's Fort ___ | 22 |
| Only four-letter Great Lake | 27 |
| Onetime New York Indian | 23 |
| One of the Lower Lakes | 22 |
| One of the HOMES lakes | 22 |
| One of five great waterways | 27 |
| One of a well-known quintet | 27 |
| One of "H.O.M.E.S." | 29 |
| Oliver Perry victory site | 25 |
| Old Ohio/New York tribe | 23 |
| Old name in railroading | 23 |
| Old Buffalo-to-Albany canal | 27 |
| Ohio/Ontario separator | 22 |
| Ohio-Ontario separator | 22 |
| Ohio county north of Huron | 26 |
| North American language | 23 |
| Niagara River's feeder | 26 |
| New York's __ Canal | 23 |
| Neighbour of Ontario | 22 |
| Neighbor of Chautauqua Lake | 27 |
| Naval battle site: 1813 | 23 |
| Naval battle site of 1813 | 25 |
| Mercyhurst College city | 23 |
| Mentor-on-the-Lake's lake | 29 |
| Lorain, Ohio's lake | 23 |
| Large North American lake | 25 |
| Language related to Wyandot | 27 |
| Lakewood, Ohio's lake | 25 |
| Lakeside Pennsylvania city | 26 |
| Lake that sounds spooky | 23 |
| Lake that borders Ohio | 22 |
| Lake surrounding Pelee Island | 29 |
| Lake south of Niagara Falls | 27 |
| Lake seen from Euclid, Ohio | 27 |
| Lake seen at Lakewood, Ohio | 27 |
| Lake on our northern border | 27 |
| Lake of the Bass Islands | 24 |
| Lake north of Cleveland | 23 |
| Lake next to Cleveland | 22 |
| Lake next to Avon Lake | 22 |
| Lake near Lake Ontario | 22 |
| Lake near Jacobs Field | 22 |
| Lake in U.S. and Canada | 23 |
| Lake in an old railroad name | 28 |
| Lake fed by the Maumee River | 28 |
| Lake fed by the Maumee | 22 |
| Lake fed by the Detroit River | 29 |
| Lake bordering New York | 23 |
| Lake bordering four states | 26 |
| Lake between Ohio and Ontario | 29 |
| Lake along which I-90 runs | 26 |
| Lake adjoining Ontario | 22 |
| Lake ___, south of London | 25 |
| Lake ___, 1813 battle site | 26 |
| Jay Gould's train company | 29 |
| It's fed by the Cuyahoga | 28 |
| It's at one end of I-79 | 27 |
| Indian of a New York region | 27 |
| I-79's northern terminus | 28 |
| Hometown of Larry Holmes | 24 |
| High-snowfall Eastern city | 26 |
| Great Lake with walleye | 23 |
| Great Lake bordering New York | 29 |
| Gannon University's home | 28 |
| Gannon University location | 26 |
| Gannon University locale | 24 |
| Gannon University home | 22 |
| Fort Presque Isle site | 22 |
| Eastern Woodlands tribe | 23 |
| DeWitt Clinton's waterway | 29 |
| Detroit River's terminus | 28 |
| Detroit River destination | 25 |
| De Witt Clinton's canal | 27 |
| Creepy-sounding lake name? | 26 |
| County west of Wyoming | 22 |
| County south of Niagara | 23 |
| County east of Sandusky | 23 |