| Canal to the Hudson River | 25 |
| Buffalo's waterfront | 24 |
| The shallowest Great Lake | 25 |
| Source of the Niagara River | 27 |
| Pennsylvania lake port | 22 |
| One of five Great ones | 22 |
| One of a watery quintet | 23 |
| Northern terminus of I-79 | 25 |
| New York's ___ Canal | 24 |
| Jay Gould's railroad | 24 |
| Fourth-largest Great Lake | 25 |
| Buffalo's body of water | 27 |
| U.S. port, or its locale | 24 |
| The "E" in HOMES | 26 |
| Site of Mercyhurst College | 26 |
| Part of Ohio's border | 25 |
| Lackawanna's partner | 24 |
| Jolliet's 1669 discovery | 28 |
| Home of Gannon University | 25 |
| Enemies of the Iroquois | 23 |
| City southwest of Buffalo | 25 |
| City on Presque Isle Bay | 24 |
| Buffalo-to-Albany canal | 23 |
| Ashtabula's waterfront | 26 |
| ___-Lackawanna Railroad | 23 |
| ___ Lackawanna Railroad | 23 |
| Western New York county | 23 |
| View from Sandusky, Ohio | 24 |
| Site of Villa Maria College | 27 |
| Railroad chartered in 1832 | 26 |
| Presque Isle's lake | 23 |
| Ontario's neighbor | 22 |
| One of a noted quintet | 22 |
| Northeastern U.S. canal | 23 |
| Name of a lake or canal | 23 |
| Lake that feeds Niagara Falls | 29 |
| Lake bordering Ontario | 22 |
| It's inferior to Superior | 29 |
| Gannon University site | 22 |
| Former lakeshore tribe | 22 |
| Canal with a mule, in song | 26 |
| Battle of Lake ___: 1813 | 24 |
| Admiral Perry victory site | 26 |
| Where the Detroit River ends | 28 |
| Warmest of the Great Lakes | 26 |
| War of 1812 siege site | 22 |
| Villa Maria College site | 24 |
| Strange-sounding waterway? | 26 |
| Strange-sounding city? | 22 |
| Strange-sounding canal? | 23 |
| Scene of Perry's victory | 28 |
| Port city of Pennsylvania | 25 |
| Pennsylvania port or its lake | 29 |
| Pelee Island's lake | 23 |
| One of five bodies of water | 27 |
| One of a notable quintet | 24 |
| One of a great quintet | 22 |
| Ohio's Lake ___ College | 27 |
| O'Neill's ___ Smith | 27 |
| Northwest Pennsylvania county | 29 |
| Northwest Pennsylvania city | 27 |
| Niagara River's source | 26 |
| New York canal opened in 1825 | 29 |
| Neighbor of Ontario and Huron | 29 |
| Name of a lake and canal | 24 |
| Member of the Cat Nation | 24 |
| Lake where Perry fought | 23 |
| Lake touching four states | 25 |
| Lake that sounds weird | 22 |
| Lake that sounds mysterious | 27 |
| Lake that sounds creepy | 23 |
| Lake in view from Cleveland | 27 |
| Joliet discovery of 1669 | 24 |
| It feeds Niagara Falls | 22 |
| Gannon University city | 22 |
| Cleveland's waterfront | 26 |
| Cleveland's body of water | 29 |
| City on a same-named lake | 25 |
| City not far from Buffalo | 25 |
| City in the Keystone State | 26 |
| Cedar Point's lake | 22 |
| Canal that opened in 1825 | 25 |
| Canal finished in 1825 | 22 |
| Buffalo's county or lake | 28 |
| A great lake for sailing? | 25 |
| "The Flagship City" | 29 |
| ___ Smith, O'Neill hero | 27 |
| Where Toledans go sailing | 25 |
| Where Perry triumphed: 1813 | 27 |
| Waterway in a folk song | 23 |
| War of 1812 shipbuilding port | 29 |
| War of 1812 battle locale | 25 |
| View from Presque Isle | 22 |
| USS Niagara docking site | 24 |
| Upstate New York county | 23 |
| U.S. Brig Niagara's port | 28 |
| Tribe with palisaded villages | 29 |
| Tribe in the Great Lakes area | 29 |
| Toledo's body of water | 26 |
| Southernmost of a wet quintet | 29 |