| Second homes for apparatchiks | 29 |
| Second highest pinochle card | 28 |
| Second highest peak in N.A. | 27 |
| Second helping, to a dieter | 27 |
| Second half of the quote | 24 |
| Second half of CLUE #2 | 22 |
| Second half of an inning | 24 |
| Second half of an audiotape | 27 |
| Second half of an album | 23 |
| Second half of a TV show? | 25 |
| Second half of a record | 23 |
| Second half of a musical | 24 |
| Second half of a doubleheader | 29 |
| Second half of a court game | 27 |
| Second half of a cocktail | 25 |
| Second half of a cassette | 25 |
| Second half of a ball game? | 27 |
| Second group in a voice vote | 28 |
| Second Greek consonant | 22 |
| Second governor of New York | 27 |
| Second generation member | 24 |
| Second floor of a home, say | 27 |
| Second emperor after Nero | 25 |
| Second drink, so to speak | 25 |
| Second draft, informally | 24 |
| Second digit of current year | 28 |
| Second digit from the right | 27 |
| Second daughter of James II | 27 |
| Second cup of coffee, e.g. | 26 |
| Second Commandment word | 23 |
| Second Commandment violators | 28 |
| Second Commandment violator | 27 |
| Second Commandment taboo | 24 |
| Second Commandment subject | 26 |
| Second commandment no-no | 24 |
| Second column from the right | 28 |
| Second city, for short | 22 |
| Second City's #1 airport | 28 |
| Second city of the U.S. | 23 |
| Second chances in school | 24 |
| Second chances for students | 27 |
| Second chance, of a sort | 24 |
| Second chance in school | 23 |
| Second chance in education? | 27 |
| Second chance in court | 22 |
| Second chance for viewers | 25 |
| Second cervical vertebra | 24 |
| Second Bull Run victor | 22 |
| Second book of the Torah | 24 |
| Second book of Moses: Abbr. | 27 |
| Second bk. of the Torah | 23 |
| Second baseman Santiago | 23 |
| Second baseman Sandberg | 23 |
| Second baseman Roberto | 22 |
| Second baseman of comedy | 24 |
| Second banana of a sort | 23 |
| Second banana in the kitchen | 28 |
| Second attempt to film | 22 |
| Second American in space | 24 |
| Second Amendment-touting gp. | 28 |
| Second Amendment topic | 22 |
| Second Amendment supporter | 26 |
| Second Amendment subject | 24 |
| Second Amendment rights org. | 28 |
| Second Amendment rights grp. | 28 |
| Second Amendment phrase | 23 |
| Second Amendment lobby | 22 |
| Second Amendment issue | 22 |
| Second amendment concern | 24 |
| Second Amendment citing gp. | 27 |
| Second Amendment advocacy gp. | 29 |
| Second Alice in Chains EP | 25 |
| Second airing of a TV show | 26 |
| Second afterthought: Abbr. | 26 |
| Second afterthought (abbr.) | 27 |
| Second addition to a ltr. | 25 |
| Second addendum to a letter | 27 |
| Second a second-story man | 25 |
| Second "four bells" | 29 |
| Secluded Hindu retreats | 23 |
| Secluded animal habitat | 23 |
| Secessionists, initially | 24 |
| Secessionist state of 1967 | 26 |
| Secaucus clock setting | 22 |
| Secant's reciprocal | 23 |
| Sec. Shultz's predecessor | 29 |
| Sec. of War: 1829–31 | 27 |
| Sec. of Transportation | 22 |
| Sec. of the Interior: 1933-46 | 29 |
| Sec. of State, 1895–97 | 29 |
| Sec. of State's aide | 24 |
| Sec. of State under D.D.E. | 26 |
| Sec. of State Powell, e.g. | 26 |
| Sec. of State nickname | 22 |
| Sec. of State after Vance | 25 |
| Sec. of Interior under F.D.R. | 29 |
| Sec. Donovan's concern | 26 |
| Sec. Brown's concern | 24 |
| SEC chairman ___ White | 22 |
| Sebastian, Bruce or John | 24 |