| Second-largest city of Italia | 29 |
| Second-largest city in Italy | 28 |
| Second-largest city in Ark. | 27 |
| Second-in-command: abbr. | 24 |
| Second-highest world capital | 28 |
| Second-highest pinochle cards | 29 |
| Second-highest pinochle card | 28 |
| Second-highest part, usually | 28 |
| Second-highest mountain | 23 |
| Second-highest choir voice | 26 |
| Second-heaviest noble gas | 25 |
| Second-hand kind of shop | 24 |
| Second-hand gal of song | 23 |
| Second-guessers' words | 26 |
| Second-guesser's forte | 26 |
| Second-generation shows | 23 |
| Second-generation Japanese | 26 |
| Second-generation boxer Ali | 27 |
| Second-generation boxer | 23 |
| Second-floor apartment | 22 |
| Second-deepest U.S. lake | 24 |
| Second-counter's opening | 28 |
| Second-closest star to Earth | 28 |
| Second-century physician | 24 |
| Second-century Greek satirist | 29 |
| Second-century B.C. ascetic | 27 |
| Second-century astronomer | 25 |
| Second-century ascetic | 22 |
| Second-century anatomist | 24 |
| Second-brightest stars | 22 |
| Second-billed performer | 23 |
| Second-best quoits pitch | 24 |
| Second-ary conversation | 23 |
| Second, with "with" | 29 |
| Second year student, shortly | 28 |
| Second wrong guess in hangman | 29 |
| Second word of many limericks | 29 |
| Second word of a limerick | 25 |
| Second word of a Latin hymn | 27 |
| Second word of a January song | 29 |
| Second word of a fairy tale | 27 |
| Second word in the ladder | 25 |
| Second word in many limericks | 29 |
| Second word in fairy tales | 26 |
| Second word in an anthem | 24 |
| Second word in a Wilder title | 29 |
| Second word in a fairy tale | 27 |
| Second word from Descartes? | 27 |
| Second winning number? | 22 |
| Second wife of Woodrow Wilson | 29 |
| Second wife of Pericles | 23 |
| Second wife of Juan Peron | 25 |
| Second wife of Henry VIII | 25 |
| Second versions of stories | 26 |
| Second verb in the Bible | 24 |
| Second up, Roberta ____ | 23 |
| Second try on a movie shot | 26 |
| Second Triumvirate member | 25 |
| Second tries, in cards | 22 |
| Second tries on the set | 23 |
| Second to ___ (the best) | 24 |
| Second to __ (the best) | 23 |
| Second time to the top | 22 |
| Second Sunday of May honoree | 28 |
| Second Sunday in May honoree | 28 |
| Second Sunday before Lent | 25 |
| Second story London visitor | 27 |
| Second step for a marksman | 26 |
| Second son of the first man | 27 |
| Second son of Jacob and Leah | 28 |
| Second smallest Teletubby | 25 |
| Second smallest state: Abbr. | 28 |
| Second smallest of the U.S.A. | 29 |
| Second smallest continent | 25 |
| Second sight, for short | 23 |
| Second sight, familiarly | 24 |
| Second sight, acronymi-cally | 28 |
| Second shot, on a movie set | 27 |
| Second serve, for example | 25 |
| Second sequel's number | 26 |
| Second sequel notation | 22 |
| Second sequel indicator | 23 |
| Second sequel designation | 25 |
| Second section, perhaps | 23 |
| Second Punic War general | 24 |
| Second point in tennis | 22 |
| Second point at Wimbledon | 25 |
| Second planet past Merkur | 25 |
| Second planet past Mercur | 25 |
| Second planet from the sun | 26 |
| Second place from the right | 27 |
| Second place acknowledgement | 28 |
| Second photographed star | 24 |
| Second person, grammatically | 28 |
| Second person's namesakes | 29 |
| Second person in the Trinity | 28 |
| Second person in the Bible? | 27 |
| Second person in the Bible | 26 |
| Second person in Genesis | 24 |
| Second person copulative | 24 |