| Seraphim, to Sevillians | 23 |
| Seraphim and cherubim, e.g. | 27 |
| Seraph's song: Var. | 23 |
| Ser, across the Pyrenees | 24 |
| Sequentially following | 22 |
| Sequential scale notes | 22 |
| Sequential list of events | 25 |
| Sequencing target, briefly | 26 |
| Sequences of sovereigns | 23 |
| Sequencer-driven music | 22 |
| Sequence with Y, sometimes | 26 |
| Sequence with a Y, sometimes | 28 |
| Sequence of ecological stages | 29 |
| Sequence late in the alphabet | 29 |
| Sequence before Friday's | 28 |
| Sequence associated with 6 | 26 |
| Sequel's tag, at times | 26 |
| Sequel writer's work? | 25 |
| Sequel to a store fire | 22 |
| Sequel to a Costner film? | 25 |
| Sequel to "Willard" | 29 |
| Sequel to "Typee" | 27 |
| Sequel set on the moon LV-426 | 29 |
| Septuagenarian's goal | 25 |
| Septiembre, por ejemplo | 23 |
| Septic tank organism, e.g. | 26 |
| Septic tank bacterium, e.g. | 27 |
| Septic or social starter | 24 |
| Septennial affliction? | 22 |
| Septembre's preceder | 24 |
| September's thirty | 22 |
| September's number | 22 |
| September sprint of sorts | 25 |
| September setting in St. Pete | 29 |
| September seasonal shift | 24 |
| September outing, usually | 25 |
| September happenings, often | 27 |
| September 23, approximately | 27 |
| September 2007 erupter | 22 |
| September 13 in old Rome | 25 |
| Sept. hrs. in South Carolina | 28 |
| Sept. 23–Oct. 22 baby | 28 |
| Sept. 12, 1978 TV debut | 23 |
| Separator of once and time | 26 |
| Separator of Mex. and Can. | 26 |
| Separator of light and dark | 27 |
| Separator of family names | 25 |
| Separator of continents | 23 |
| Separator at Wimbledon | 22 |
| Separation of a compound word | 29 |
| Separating, as lines of type | 28 |
| Separating via strainer | 23 |
| Separates with a sieve | 22 |
| Separates meaningfully | 22 |
| Separates into threads | 22 |
| Separates into filaments | 24 |
| Separates for the wash | 22 |
| SePArately distinct lettering | 29 |
| Separated, as with a knife | 26 |
| Separated, as a stream | 22 |
| Separated, as a couple | 22 |
| Separated religious bodies | 26 |
| Separated by a wide chasm | 25 |
| Separate-checks situation | 25 |
| Separate-checks arrangement | 27 |
| Separate, like gold and dirt | 28 |
| Separate, as with a tool | 24 |
| Separate, as whites and darks | 29 |
| Separate, as flour or ashes | 27 |
| Separate, as chain parts | 24 |
| Separate wheat from chaff | 25 |
| Separate through percolation | 28 |
| Separate the twisted strands | 28 |
| Separate magazine leaf | 22 |
| Separate leaf in a book | 23 |
| Separate into like groups | 25 |
| Separate into groups of two | 27 |
| Separate grains from hulls | 26 |
| Separate grain from chaff | 25 |
| Separate chaff from grain | 25 |
| Separate by cutting off | 23 |
| Separate by color, say | 22 |
| Sepal's counterpart | 23 |
| SEP-___ (investing option) | 26 |
| Seoul's nation, for short | 29 |
| Seoul's home: Abbr. | 23 |
| Seoul music is played there | 27 |
| Seoul music can be heard here | 29 |
| Seoul brother, for one | 22 |
| SentryÂ's directive | 27 |
| Sentry's sine qua non | 25 |
| Sentry's post, perhaps | 26 |
| Sentry's imperative | 23 |
| Sentry's first command | 26 |
| Sentry's attribute | 22 |
| Sentry covered with smudges? | 28 |
| Sentiments of an electorate | 27 |
| Sentiments from a hepcat? | 25 |
| Sentimentalized writings | 24 |
| Sentimentalized nostalgically | 29 |