| Major telescope maker | 21 |
| Major tennis event | 18 |
| Major tennis events | 19 |
| Major tennis tourney | 20 |
| Major test | 10 |
| Major tests | 11 |
| Major Thai export | 17 |
| Major theater chain | 19 |
| Major thoroughfare | 18 |
| Major time period | 17 |
| Major time periods | 18 |
| Major time span | 15 |
| Major tin exporter | 18 |
| Major tin producer | 18 |
| Major tourist draw | 18 |
| Major tournaments for clergymen? | 32 |
| Major tourneys | 14 |
| Major tractor manufacturer | 26 |
| Major trading center of Arabia | 30 |
| Major trailer | 13 |
| Major transfer spots | 20 |
| Major transformation | 20 |
| Major transgression | 19 |
| Major transition point | 22 |
| Major transportation route | 26 |
| Major transportation routes | 27 |
| Major trial | 11 |
| Major troubles | 14 |
| Major TV brand | 14 |
| Major TV broadcaster | 20 |
| Major TV logo | 13 |
| Major TV maker | 14 |
| Major TV network | 16 |
| Major U of M rival | 18 |
| Major U. S. river | 17 |
| Major U.S. farm export | 22 |
| Major U.S. lake | 15 |
| Major U.S. Spanish-language daily | 33 |
| Major U.S./Mexico border crossing | 33 |
| Major U.S.oil hub | 17 |
| Major UK record label | 21 |
| Major under Custer | 18 |
| Major undertaking | 17 |
| Major undertaking? | 18 |
| Major undertakings | 18 |
| Major unrest | 12 |
| Major upset | 11 |
| Major upset, say | 16 |
| Major urban rd. | 15 |
| Major US defense contractor | 27 |
| Major US metal processor | 24 |
| Major US punk club of the 1970s | 31 |
| Major util. | 11 |
| Major vein | 10 |
| Major vessel | 12 |
| Major video game franchise | 26 |
| Major Vietnam port | 18 |
| Major W.W. II Japanese base on New Guinea | 41 |
| Major water line | 16 |
| Major waterway of Eastern Europe | 32 |
| Major West German port | 22 |
| Major Winchester portrayer David Ogden | 38 |
| Major work | 10 |
| Major work by Virgil | 20 |
| Major work from the Latin for "work" | 46 |
| Major work in grad sch. | 23 |
| Major work of poetry | 20 |
| Major works | 11 |
| Major World Cup sponsor | 23 |
| Major wreck | 11 |
| Major WWI killer | 16 |
| Major Wyoming resource | 22 |
| Major ___ | 9 |
| Major ___ (tarot deck division) | 31 |
| Major ___ of radio fame | 23 |
| Major ____ | 10 |
| Major ____: chief steward | 25 |
| Major _____ | 11 |
| Major's follower in Britain | 31 |
| Major's group | 17 |
| Major's minor role | 22 |
| Major's opp. | 16 |
| Major's successor | 21 |
| Major's superior | 20 |
| Major, as a road | 16 |
| Major, but not minor | 20 |
| Major, for example | 18 |
| Major, for one | 14 |
| Major, in music | 15 |
| Major, or Minor | 15 |
| Major- -- (butler) | 18 |
| Major-chord note | 16 |
| Major-ette's prop | 21 |
| Major-label critic DiFranco | 27 |
| Major-league | 12 |
| Major-league career leader in at bats | 37 |
| Major-league manager Joe | 24 |
| Major-league manager Tony | 25 |
| Major-league manager who won World Series in both leagues | 57 |
| Major-league team member through 2004 | 37 |