| Major network, once | 19 |
| Major New York-to-Tennessee route | 33 |
| Major news agcy. | 16 |
| Major news media | 16 |
| Major newspapers | 16 |
| Major nickel exporter | 21 |
| Major Nile cataract locale | 26 |
| Major no-no | 11 |
| Major NPR supporter | 19 |
| Major nuisance | 14 |
| Major nuisances | 15 |
| Major Nuovo Testamento writer | 29 |
| Major occasion | 14 |
| Major of comics | 15 |
| Major of many a poli sci student | 32 |
| Major oil corp. | 15 |
| Major oil exporter | 18 |
| Major oil hub | 13 |
| Major oil port | 14 |
| Major oil refinery port | 23 |
| Major oil source | 16 |
| Major Old West cattle route | 27 |
| Major olive oil exporter | 24 |
| Major opening | 13 |
| Major opening? | 14 |
| Major openings, e.g. | 20 |
| Major operation? | 16 |
| Major or disk follower | 22 |
| Major or kitchen follower | 25 |
| Major or major general | 22 |
| Major or Minor | 14 |
| Major or minor arm muscle | 25 |
| Major or Minor bear | 19 |
| Major or Minor beginning | 24 |
| Major or minor constellation | 28 |
| Major or minor follower | 23 |
| Major or Minor lead-in | 22 |
| Major or Minor preceder | 23 |
| Major or Minor predecessor | 26 |
| Major or Minor tarot card group | 31 |
| Major or Minor? | 15 |
| Major or Mrs. of old comics | 27 |
| Major or Santa | 14 |
| Major or Thatcher, e.g. | 23 |
| Major or usher chaser | 21 |
| Major or usher suffix | 21 |
| Major ore of uranium | 20 |
| Major org. representing entertainers and athletes | 49 |
| Major outlet | 12 |
| Major oven maker | 16 |
| Major overhaul | 14 |
| Major overland migration route | 30 |
| Major pain | 10 |
| Major paper, for short | 22 |
| Major paperback publisher | 25 |
| Major part | 10 |
| Major part of a tooth | 21 |
| Major part of sumo wrestlin'? | 33 |
| Major part or the whole thing | 29 |
| Major parties | 13 |
| Major party | 11 |
| Major Pasadena thoroughfare | 27 |
| Major patent seller of 2013 | 27 |
| Major PBS contributor | 21 |
| Major PBS supporter | 19 |
| Major peanut purchaser | 22 |
| Major peninsula | 15 |
| Major personal annoyance | 24 |
| Major Peruvian export | 21 |
| Major pest in the South | 23 |
| Major PGA sponsor | 17 |
| Major physics event | 19 |
| Major pickup maker | 18 |
| Major piece of cribbage equipment | 33 |
| Major Pierce portrayer | 22 |
| Major pipe | 10 |
| Major pipeline | 14 |
| Major player in the movie biz? | 30 |
| Major player on '70s and '80s TV | 40 |
| Major player? | 13 |
| Major poem | 10 |
| Major point on the Oregon Trail (with "The") | 54 |
| Major port in Japan | 19 |
| Major port of Iraq | 18 |
| Major port of Old Rome | 22 |
| Major port of Ukraine | 21 |
| Major port on Osaka Bay | 23 |
| Major port, e.g. | 16 |
| Major portion | 13 |
| Major portion of oneÂ’s grade, often | 39 |
| Major Postal Service client | 27 |
| Major potato producer | 21 |
| Major Prado artist | 18 |
| Major prank | 11 |
| Major presidential caucus state | 31 |
| Major pro-choice org. | 21 |
| Major processing center | 23 |
| Major producer of raspberries | 29 |
| Major producers of oil | 22 |
| Major production | 16 |