| Major handgun manufacturer | 26 |
| Major happening | 15 |
| Major happenings | 16 |
| Major hassle | 12 |
| Major Hawaiian plant | 20 |
| Major headache | 14 |
| Major headaches | 15 |
| Major heart vessel | 18 |
| Major heart vessels | 19 |
| Major highway | 13 |
| Major highway from Fla. to Calif. | 33 |
| Major holder of gold | 20 |
| Major Hollywood attraction | 26 |
| Major Hollywood thoroughfare | 28 |
| Major home security corp. | 25 |
| Major Hoople | 12 |
| Major Hoople expletive | 22 |
| Major Hoople's "drat" | 35 |
| Major Hoople's "whoops" | 37 |
| Major Hoople's cries | 24 |
| Major Hoople's cry | 22 |
| Major Hoople's epitaph | 26 |
| Major Hoople's exclamation, in the comics | 45 |
| Major Hoople's expletive | 28 |
| Major Hoople's expletives | 29 |
| Major Hoople's first name | 29 |
| Major Hoople's holler | 25 |
| Major Hoople's outburst, in old comics | 42 |
| Major Hoople's word | 23 |
| Major Hoople, for one | 21 |
| Major hostilities | 17 |
| Major Houlihan portrayer | 24 |
| Major Houlihan, e.g. | 20 |
| Major hub of Japan | 18 |
| Major hurdle, metaphorically | 28 |
| Major hurricane of 2005 | 23 |
| Major hurricane of 2008 | 23 |
| Major impact, as of an attack | 29 |
| Major in | 8 |
| Major in astronomy? | 19 |
| Major in golf | 13 |
| Major in govt. | 14 |
| Major inconvenience | 19 |
| Major inconveniences | 20 |
| Major Indian export | 19 |
| Major indignation | 17 |
| Major Indonesian export | 23 |
| Major industrial center near Manchester | 39 |
| Major industry of Madeira | 25 |
| Major influence in '60s music | 33 |
| Major injustice | 15 |
| Major insurance risk | 20 |
| Major interest, slangily | 24 |
| Major Internet service provider, for short | 42 |
| Major intersection | 18 |
| Major introduction? | 19 |
| Major investigation | 19 |
| Major Iraqi river | 17 |
| Major irritant | 14 |
| Major irritant for American colonists | 37 |
| Major ISP | 9 |
| Major Istanbul attraction | 25 |
| Major Italian fashion house | 27 |
| Major Italian tourist site | 26 |
| Major Japanese carrier | 22 |
| Major Japanese city | 19 |
| Major Japanese seaport | 22 |
| Major jazz label | 16 |
| Major jerk | 10 |
| Major John ___ | 14 |
| Major Joppolo's post | 24 |
| Major Joppolo's town | 24 |
| Major Kazakhstani export | 24 |
| Major Kenyan export | 19 |
| Major key | 9 |
| Major key that uses all five black keys on a piano | 50 |
| Major keys? | 11 |
| Major KFC supplier | 18 |
| Major kitchen appliance | 23 |
| Major klutzes | 13 |
| Major L.A. Avenue | 17 |
| Major label broken up in 2012 | 29 |
| Major land mass | 15 |
| Major landing site | 18 |
| Major landmass | 14 |
| Major lang. | 11 |
| Major Lazer "___ Me" | 30 |
| Major leader? | 13 |
| Major league ball team | 22 |
| Major League Baseball announcement recognizing top performance | 62 |
| Major League Baseball commissioner | 34 |
| Major League Baseball commissioner Bud | 38 |
| Major League Baseball family name | 33 |
| Major League Baseball Players Association director | 50 |
| Major League Baseball V.I.P. | 28 |
| Major League Baseball's oldest rookie ever | 46 |
| Major League bird | 17 |
| Major league brothers' name | 31 |
| Major league career? | 20 |
| Major league family name | 24 |