| Major East Coast hwy. | 21 |
| Major ecological community | 26 |
| Major econ. index | 17 |
| Major education supporter | 25 |
| Major eight-track tape maker | 28 |
| Major electronics co. | 21 |
| Major elephant feature | 22 |
| Major emergencies | 17 |
| Major employer | 14 |
| Major employer in Detroit | 25 |
| Major employer in Hawaii | 24 |
| Major employer in Hiroshima | 27 |
| Major ender | 11 |
| Major ending | 12 |
| Major ending, often | 19 |
| Major ending? | 13 |
| Major endocrine gland | 21 |
| Major entertainment gp.? | 24 |
| Major entertainment? | 20 |
| Major epidemiological subject | 29 |
| Major error in soccer | 21 |
| Major Eur. oil exporter | 23 |
| Major Eur. oil producer | 23 |
| Major European coffee port | 26 |
| Major European river | 20 |
| Major European waterway | 23 |
| Major event | 11 |
| Major event for a law student | 29 |
| Major event in golf or tennis | 29 |
| Major event of 1812 | 19 |
| Major exam | 10 |
| Major expense for an airline | 28 |
| Major export from the islets of Langerhans | 42 |
| Major export of Albania and South Africa | 40 |
| Major export of Brazil and Australia | 36 |
| Major export of Ivory Coast | 27 |
| Major exporter of coconut oil | 29 |
| Major exporter of handmade carpets | 34 |
| Major exporter of nickel | 24 |
| Major extension? | 16 |
| Major extensions? | 17 |
| Major factor in Korean independence | 35 |
| Major factor in postal rates | 28 |
| Major fair | 10 |
| Major fall | 10 |
| Major fear | 10 |
| Major fiction | 13 |
| Major fight | 11 |
| Major figure | 12 |
| Major figure in "Paradise Lost" | 41 |
| Major figure in space? | 22 |
| Major figures | 13 |
| Major finale | 12 |
| Major finale? | 13 |
| Major finales? | 14 |
| Major financial concern | 23 |
| Major finish | 12 |
| Major finish? | 13 |
| Major fire | 10 |
| Major fish exporter | 19 |
| Major Fla.-Calif. hwy. | 22 |
| Major Fla.-to-Calif. route | 26 |
| Major flare-up | 14 |
| Major flatware maker | 20 |
| Major flop | 10 |
| Major follower | 14 |
| Major follower? | 15 |
| Major followers | 15 |
| Major followers? | 16 |
| Major following? | 16 |
| Major food service company | 26 |
| Major football competition | 26 |
| Major for civic-minded frosh | 28 |
| Major force in chess | 20 |
| Major forces | 12 |
| Major French airport | 20 |
| Major French city | 17 |
| Major French newspaper | 22 |
| Major French publisher of reference works | 41 |
| Major fruit canner | 18 |
| Major function | 14 |
| Major functions | 15 |
| Major gains | 11 |
| Major General Jesse Lee ___ | 27 |
| Major General Wallace | 21 |
| Major German export | 19 |
| Major German river, in German | 29 |
| Major German river, to a Frenchman | 34 |
| Major Germanic god | 18 |
| Major gift for a teen | 21 |
| Major glitch | 12 |
| Major global crop | 17 |
| Major gold exporter of Africa | 29 |
| Major gold-mining area, with "the" | 44 |
| Major golf event | 16 |
| Major golf tourney | 18 |
| Major golf tourneys | 19 |
| Major govt.-owned power producer | 32 |
| Major growth areas | 18 |
| Major growth areas? | 19 |