| Major California vintner | 24 |
| Major campaign contributor | 26 |
| Major can maker | 15 |
| Major Canadian short-story writer | 33 |
| Major car manufacturer | 22 |
| Major car part | 14 |
| Major catch for a bride? | 24 |
| Major caucus site | 17 |
| Major cause | 11 |
| Major cause of inflation | 24 |
| Major cause of inflation? | 25 |
| Major Côte d'Ivoire export | 33 |
| Major celeb | 11 |
| Major character in the bestseller "Disney War" | 56 |
| Major chaser | 12 |
| Major chess piece | 17 |
| Major Chicago tourist attraction | 32 |
| Major Chinese dialect | 21 |
| Major Chinese energy source | 27 |
| Major Chinese seaport | 21 |
| Major chip maker | 16 |
| Major chipmaker | 15 |
| Major chunk of Earth's surface | 34 |
| Major city of ancient Crete | 27 |
| Major city of Norway | 20 |
| Major city of southwest Colombia | 32 |
| Major city off the coast of China | 33 |
| Major city on the Missouri | 26 |
| Major city on the Ruhr | 22 |
| Major civic bldgs. | 18 |
| Major cleanups follow them | 26 |
| Major closing? | 14 |
| Major club | 10 |
| Major coca producer | 19 |
| Major cocoa exporter | 20 |
| Major cocoa producer | 20 |
| Major cocoa-producing country | 29 |
| Major coffee exporter | 21 |
| Major coffee-bean producer | 26 |
| Major cold spells | 17 |
| Major coll. fraternity | 22 |
| Major college football's winningest coach | 45 |
| Major command | 13 |
| Major company in metallic products | 34 |
| Major company renamed in 1997 | 29 |
| Major complication | 18 |
| Major component of kidney stones | 32 |
| Major component of Saturn's rings | 37 |
| Major component of soapstone | 28 |
| Major component of the euro symbol | 34 |
| Major conclusion | 16 |
| Major conclusion? | 17 |
| Major conflict | 14 |
| Major conflicts | 15 |
| Major constellation | 19 |
| Major constellation? | 20 |
| Major contributor to Central Park's Strawberry Fields | 57 |
| Major cooling-off period | 24 |
| Major copper exporter | 21 |
| Major copper producer | 21 |
| Major corporation that was headquartered in Pennsylvania | 56 |
| Major cotton producer | 21 |
| Major country with the longest life expectancy | 46 |
| Major course | 12 |
| Major cover-up | 14 |
| Major crime | 11 |
| Major criminal | 14 |
| Major criminals | 15 |
| Major crossroads | 16 |
| Major cruise port | 17 |
| Major Cuban export | 18 |
| Major cymbal brand | 18 |
| Major Czech export | 18 |
| Major D.C. employer | 19 |
| Major D.C. lobby | 16 |
| Major DC lobby | 14 |
| Major De Sica film | 18 |
| Major defeat | 12 |
| Major defense contractor | 24 |
| Major defense corp. | 19 |
| Major Defense Dept. contractor | 30 |
| Major departure | 15 |
| Major depression out West? | 26 |
| Major diamond exporter | 22 |
| Major digital satellite service provider | 40 |
| Major dis | 9 |
| Major disasters | 15 |
| Major discount brokerage | 24 |
| Major disruption | 16 |
| Major divider | 13 |
| Major division | 14 |
| Major division of a long poem | 29 |
| Major division of geological time | 33 |
| Major divisions in biology | 26 |
| Major divisions of geological time | 34 |
| Major divisions, in biology | 27 |
| Major downer? | 13 |
| Major drug dealer | 17 |
| Major dud | 9 |
| Major e-mail deliverer | 22 |