| Major affiliation | 17 |
| Major African conflict | 22 |
| Major African humanitarian concern of the 2000s | 47 |
| Major African language | 22 |
| Major African river | 19 |
| Major Air France terminus | 25 |
| Major airline | 13 |
| Major airline until 2001 | 24 |
| Major airport | 13 |
| Major airports | 14 |
| Major airports, e.g. | 20 |
| Major Alaskan gold rush city | 28 |
| Major Algerian port | 19 |
| Major alliance | 14 |
| Major alteration of a business structure, for short | 51 |
| Major aluminum producer | 23 |
| Major American export | 21 |
| Major American network | 22 |
| Major ancient construction project | 34 |
| Major and Blair, for short | 26 |
| Major and captain | 17 |
| Major and captain, e.g. | 23 |
| Major and Minor | 15 |
| Major and minor starter | 23 |
| Major and minor, in music | 25 |
| Major and private, e.g. | 23 |
| Major and rock endings | 22 |
| Major and usher followers | 25 |
| Major animal? | 13 |
| Major annoyance | 15 |
| Major annoyances | 16 |
| Major annual U.K. festival | 26 |
| Major apostle | 13 |
| Major appliance | 15 |
| Major apprehension | 18 |
| Major arteries | 14 |
| Major artery | 12 |
| Major artery in Philadelphia | 28 |
| Major artery through San Antonio | 32 |
| Major artery: Abbr. | 19 |
| Major Asian carrier, for short | 30 |
| Major assaults | 14 |
| Major at Columbia | 17 |
| Major at Cornell | 16 |
| Major Atlanta thoroughfare | 26 |
| Major Atlantic Ocean feeder | 27 |
| Major ATM maker | 15 |
| Major ATM manufacturer | 22 |
| Major attachment | 16 |
| Major attachment? | 17 |
| Major attar source | 18 |
| Major Aussie airport, on tags | 29 |
| Major Australian network | 24 |
| Major Australian watercourse | 28 |
| Major auto part | 15 |
| Major auto race, briefly | 24 |
| Major auto race, shortly | 24 |
| Major babe | 10 |
| Major Baltic port | 17 |
| Major banking center | 20 |
| Major Baroque composer | 22 |
| Major Baroque composer's monogram | 37 |
| Major Baroque composer's signature | 38 |
| Major baseball league | 21 |
| Major bashes | 12 |
| Major birth news | 16 |
| Major Black Sea port | 20 |
| Major blood carrier | 19 |
| Major blood conveyor | 20 |
| Major blood group | 17 |
| Major blood line | 16 |
| Major blood lines | 17 |
| Major blood supplier | 20 |
| Major blood vessel | 18 |
| Major blood vessels | 19 |
| Major bloodline | 15 |
| Major bloodline? | 16 |
| Major blows | 11 |
| Major blueberry-producing state | 31 |
| Major blunders | 14 |
| Major body arteries | 19 |
| Major body vessel | 17 |
| Major Boeing client | 19 |
| Major bollix | 12 |
| Major book about a leader of the lighter industry? | 50 |
| Major bore | 10 |
| Major Boston street | 19 |
| Major Bowes updated? | 20 |
| Major Bowes's hour | 22 |
| Major brand in heating and air conditioning | 43 |
| Major British publisher | 23 |
| Major broadcaster | 17 |
| Major budget item | 17 |
| Major bummer | 12 |
| Major bummers | 13 |
| Major burden | 12 |
| Major C.P.A. employer | 21 |
| Major CA airport | 16 |
| Major Cali music store | 22 |
| Major Calif.-to-Fla. route | 26 |