| Cause to become admired | 23 |
| Cause to be well-liked | 22 |
| Do one's darnedest | 22 |
| Determined undertaking | 22 |
| Suffix for open or rear | 23 |
| "The song is ___" | 27 |
| Broke off, as a relationship | 28 |
| Word with open or rear | 22 |
| Sebadoh "Open ___" | 28 |
| Rear-__: hit from behind | 24 |
| Ending for open or rear | 23 |
| Dropped the curtain on | 22 |
| Brought to a conclusion | 23 |
| Attachment to open or rear | 26 |
| Attachment for open or rear | 27 |
| Moved on, relationshipwise | 26 |
| Discontinued a relationship | 27 |
| Broke up with the girlfriend | 28 |
| Native to a particular area | 27 |
| Prevalent, as in a locale | 25 |
| Particular to a region | 22 |
| Native to a certain region | 26 |
| Characteristic of an area | 25 |
| Rear-___ (road mishap) | 22 |
| Rear-___ (certain accident) | 27 |
| "Bitter" follower | 27 |
| Word with tail or bitter | 24 |
| Orson Scott Card protagonist | 28 |
| Word after week or rear | 23 |
| Word after East or West | 23 |
| The rear of rear, perhaps | 25 |
| Tail's tail, at times | 25 |
| Tail-___ (rearmost one) | 23 |
| Rear-___ (car accident) | 23 |
| Rear for rear, perhaps | 22 |
| German swimmer Kornelia | 23 |
| Follower of rear or week | 24 |
| Follower of bitter or tail | 26 |
| East ___ (certain Londoner) | 27 |
| Bitter or week follower | 23 |
| 2013 sci-fi film title role | 27 |
| Nobelist in Medicine: 1954 | 26 |
| Co-Nobelist in Medicine: 1954 | 29 |
| Nobelist in medicine, 1954 | 26 |
| Nobelist for Medicine: 1954 | 27 |
| Medical Nobelist in 1954 | 24 |
| Bitter-___ (persistent folks) | 29 |
| Final stage of a chess match | 28 |
| Final stage in a chess match | 28 |
| Happy time in many a film | 25 |
| Bad thing to give away | 22 |
| Nerves and novels have them | 27 |
| Bad things to give away | 23 |
| Some games have multiple ones | 29 |
| "The ___ near!" | 25 |
| "The ___ near" | 24 |
| "The __ near!" | 24 |
| "The --- near!" | 25 |
| "The _____ near" | 26 |
| 'The -- near!' | 22 |
| Send a Dear John letter | 23 |
| Call the whole thing off | 24 |
| Say "Enough!" | 23 |
| Break off a relationship | 24 |
| Write a Dear John letter | 24 |
| Dissolve a relationship | 23 |
| Call off the relationship | 25 |
| Break up the relationship | 25 |
| ___ all (do oneself in) | 23 |
| Salad vegetable, perhaps | 24 |
| White-leaved vegetable | 22 |
| Curly-edged salad leaves | 24 |
| Belgian ___ (salad green) | 25 |
| Alternative to lettuce | 22 |
| Alternative to escarole | 23 |
| Plants used for salads | 22 |
| Greens with frilled edges | 25 |
| Curly-edged salad ingredients | 29 |
| Like a Möbius strip | 22 |
| Beach Boys album of 1974 | 24 |
| Clarifying article attachment | 29 |
| Place for additional info | 25 |
| Chapter explanation, e.g. | 25 |
| Back-of-the-book listings | 25 |
| Explanatory text additions | 26 |
| Inner, in combinations | 22 |
| Opposite of "ecto" | 28 |
| It means "outer" | 26 |
| Within, in combinations | 23 |
| Prefix with -derm or -therm | 27 |
| Prefix denoting inside | 22 |
| Scope or morph preceder | 23 |
| Root canal, in dentist-speak | 28 |
| Prefix with skeleton or spore | 29 |
| Prefix with skeleton or plasm | 29 |
| Prefix with scope or skeleton | 29 |
| Prefix with plasm or morphic | 28 |
| Prefix with blast or carp | 25 |
| Prefix for skeleton or spore | 28 |
| Prefix for morph or skeletal | 28 |