| What analgesics are to pain | 27 |
| What an XXXL jacket is, for many | 32 |
| What an X-Acto knife might make | 31 |
| What an X may indicate | 22 |
| What an usher will do | 21 |
| What an urban maid may watch | 28 |
| What an up-and-coming band wants to snag | 40 |
| What an unwavering hero in westerns does | 40 |
| What an unrequited lover carries | 32 |
| What an unevenly milked cow might have? | 39 |
| What an unemployed person hunts for | 35 |
| What an underwater gunner can do | 32 |
| What an underline might indicate | 32 |
| What an unappealing offer might get | 35 |
| What an umpire's indicator indicates | 40 |
| What an umpire makes | 20 |
| What an ump's protector protects | 36 |
| What an umbrella may provide | 28 |
| What an SRO sign might portend | 30 |
| What an RN supplies | 19 |
| What an RN dispenses | 20 |
| What an R.N. takes | 18 |
| What an R.N. provides | 21 |
| What an R.N. might take | 23 |
| What an R.N. gives | 18 |
| What an R.N. administers | 24 |
| What an overloaded bookshelf does | 33 |
| What an ovate fellow did in a rhyme | 35 |
| What an outturned palm may mean | 31 |
| What an outstanding witness provides | 36 |
| What an outfielder does for practice | 36 |
| What an out-turned palm may mean | 32 |
| What an out patient may be in? | 30 |
| What an out patient may be in | 29 |
| What an otoscope explores | 25 |
| What an ostiary guards | 22 |
| What an orthodontist works on | 29 |
| What an orchestral trapper can do | 33 |
| What an orchestra tunes to | 26 |
| What an optometrist at a kindergarten examines? | 47 |
| What an optimist has | 20 |
| What an optimist envisions | 26 |
| What an optimist always looks on | 32 |
| What an optimist always has | 27 |
| What an ophthalmologist does | 28 |
| What an oozy thing might ooze | 29 |
| What an onychophagist bites | 27 |
| What an onion may produce | 25 |
| What an oneirocritic interprets | 31 |
| What an old-timer may be called | 31 |
| What an old yearbook may elicit | 31 |
| What an old sci-fi comics fan might see? | 40 |
| What an old comedian chomps | 27 |
| What an old bra gives? | 22 |
| What an oil millionaire has? | 28 |
| What an ogler gives | 19 |
| What an office seeker seeks | 27 |
| What an offer needs? | 20 |
| What an odometer measures | 25 |
| What an obi accessorizes | 24 |
| What an obedient dog may do | 27 |
| What an obedient dog does, sometimes | 36 |
| What an obedient dog does on command | 36 |
| What an MC wears | 16 |
| What an MC grips | 16 |
| What an M.D. hears, sometimes | 29 |
| What an M.A. might go on to earn | 32 |
| What an M&M does | 20 |
| What an ivory tickler's hands are on | 40 |
| What an Italian wheeler-dealer wants? | 37 |
| What an Italian angel plays? | 28 |
| What an issue must be before a court | 36 |
| What an issei might enroll in: Abbr. | 36 |
| What an iPod plays in | 21 |
| What an IOU signifies | 21 |
| What an investor builds | 23 |
| What an investigator seeks | 26 |
| What an inventor might try to build | 35 |
| What an intersection may have | 29 |
| What an interrogator might administer | 37 |
| What an integral might be used to calculate | 43 |
| What an integral measures | 25 |
| What an integral calculates | 27 |
| What an insomniac would like to do, minimally | 45 |
| What an insomniac would like to do | 34 |
| What an injured player goes through | 35 |
| What an injured NBA star may experience? | 40 |
| What an information booth has | 29 |
| What an influential person has | 30 |
| What an inflectional ending is added to | 39 |
| What an inflammatory statement is intended to do | 48 |
| What an inertial balance measures | 33 |
| What an inept surgeon might do? | 31 |
| What an inductee takes | 22 |
| What an imp never wears | 23 |
| What an idea comes to | 21 |
| What an F may indicate | 22 |
| What an exterminator leads? | 27 |
| What an express often whizzes by: Abbr. | 39 |
| What an exploding microwave can make? | 37 |