| Sir Francis Drake ship | 22 |
| Sir Francis and family | 22 |
| Sir Edward, the composer | 24 |
| Sir Edmund's challenge | 26 |
| Sir Edmund P. Hillary, e.g. | 27 |
| Sir Christopher the architect | 29 |
| Sir Charles's pet fish? | 27 |
| Sir Charles's lady | 22 |
| Sir Arthur Sullivan opera | 25 |
| Sir Arthur Conan and family | 27 |
| Sir Anthony's family | 24 |
| Sir Anthony and family | 22 |
| Sir Anthony and Clarissa | 24 |
| Sir Anthony and family | 23 |
| Sips slowly, as a drink | 23 |
| SIPS LAGER ON GIN(anag.) | 24 |
| Sipper's accessory | 22 |
| Siphon to the last drop | 23 |
| Siphon off, as support | 22 |
| Sioux warrior's trophy | 26 |
| Sioux war bonnets, e.g. | 23 |
| Sioux speaker of Oklahoma | 25 |
| Sioux Lookout setting: Abbr. | 28 |
| Sioux Falls-to-St. Paul dir. | 28 |
| Sioux Falls is there: abbr. | 27 |
| Sioux City's state | 22 |
| Sioux City's locale | 23 |
| Siouan-speaking tribe members | 29 |
| Siouan-speaking Indians | 23 |
| Siouan speaker of Oklahoma | 26 |
| Siouan speaker from Oklahoma | 28 |
| Siouan language or tribe | 24 |
| Sinusitis treater, briefly | 26 |
| Sinuses or Roman halls | 22 |
| Sinus-clearing condiment | 24 |
| Sinus specialists, for short | 28 |
| Sinus specialists, briefly | 26 |
| Sinus specialist: Abbr. | 23 |
| Sinus specialist, succinctly | 28 |
| Sinus specialist, for short | 27 |
| Sinus specialist, briefly | 25 |
| Sinus of Valsalva locale | 24 |
| Sinus infection symptom | 23 |
| Sinus headache treater: Abbr. | 29 |
| Sinuous Nile creatures | 22 |
| Sinuous Mideast entertainer | 27 |
| Sinuous comics villain | 22 |
| Sino-Soviet border river | 24 |
| Sino-Russian border river | 25 |
| Sino-Japanese War subject | 25 |
| Sino-Japanese War statesman | 27 |
| Sinners, Biblically speaking | 28 |
| Sinner's self-abasement | 27 |
| Sinner's punishment | 23 |
| Sinner's motivator? | 23 |
| Sinn ___, Irish society | 23 |
| Sinn ___ (Irish society) | 24 |
| Sinn ___ (Irish organization) | 29 |
| Sinn Feiner's org. | 22 |
| Sinn Fein leader Adams | 22 |
| Sinn Fein ally, briefly | 23 |
| Sinless Tina has this quality | 29 |
| Sinks, as a short putt | 22 |
| Sinks to the bottom, as silt | 28 |
| Sinks the cueball, e.g. | 23 |
| Sinks one's teeth into | 26 |
| Sinks below the horizon | 23 |
| Sinks a six-incher, say | 23 |
| Sinking-ship deserters | 22 |
| Sinking ship's signal | 25 |
| Sinking ship's evacuee | 26 |
| Sinking ship's deserter | 27 |
| Sinking feeling outburst? | 25 |
| Sinkhole creation, maybe | 24 |
| Sinkers may result in these | 27 |
| Sinker of the Lusitania | 23 |
| Sink-to-sewer connection | 24 |
| Sink-side item, perhaps | 23 |
| Sink, as a snooker ball | 23 |
| Sink, as a derelict ship | 24 |
| Sink, as a billiard ball | 24 |
| Sink's alternative | 22 |
| Sink one's teeth into | 25 |
| Sink like a soufflé | 22 |
| Sink down in the middle | 23 |
| Sink below the surface | 22 |
| Sink below the horizon | 22 |
| Sink as low as one can | 22 |
| Sinister, manipulative type | 27 |
| Sinister cinematic street | 25 |
| Sinise-Kanakaredes drama | 24 |
| Sinise's CBS series | 23 |
| Singularly impressive bust? | 27 |
| Singular performances? | 22 |
| Singular or plural pronoun | 26 |
| Singular operatic performance | 29 |
| Singular club performer? | 24 |
| Singular Christmas toy? | 23 |
| Singular Bee Gees song? | 23 |
| Singular 1960 musical? | 22 |