| Lead and tin alloy | 18 |
| Lead as a group | 15 |
| Lead astray | 11 |
| Lead attorney's associate | 29 |
| Lead balloon | 12 |
| Lead balloon, so to speak | 25 |
| Lead batter | 11 |
| Lead Belly classic "Goodnight, ___" | 45 |
| Lead bug in "A Bug's Life" | 40 |
| Lead by the hand | 16 |
| Lead car, sometimes | 19 |
| Lead ceremoniously | 18 |
| Lead character in "Footloose" | 39 |
| Lead character in "Grease"? | 37 |
| Lead character in "Jerry Maguire" | 43 |
| Lead character in "Planet of the Apes" | 48 |
| Lead character in "Saint Joan" | 40 |
| Lead character in "Salem's Lot"? | 46 |
| Lead character in "Zoolander"? | 40 |
| Lead character in a Mario Puzo novel | 36 |
| Lead character in Larry McMurtry's "Lonesome Dove" | 64 |
| Lead character in seasons 1-3 of "Homeland" | 53 |
| Lead character on "Pushing Daisies" | 45 |
| Lead character on "Saved by the Bell" | 47 |
| Lead character on TV's "The Pretender" | 52 |
| Lead characters in "Mork & Mindy"? | 48 |
| Lead characters in "No, No, Nanette" | 46 |
| Lead dancer in a ballet company | 31 |
| Lead down the aisle | 19 |
| Lead down the garden path | 25 |
| Lead film festival characters? | 30 |
| Lead follower | 13 |
| Lead followers? | 15 |
| Lead for a dog | 14 |
| Lead for a Lab | 14 |
| Lead for Chan | 13 |
| Lead for Charlie Chan | 21 |
| Lead for Columbo | 16 |
| Lead for D.B. Russell | 21 |
| Lead for glass | 14 |
| Lead for mode or carte | 22 |
| Lead for Poirot | 15 |
| Lead for Seabiscuit | 19 |
| Lead from a mountain? | 21 |
| Lead from the dugout | 20 |
| Lead guitarist of AC/DC | 23 |
| Lead guitarist's moment | 27 |
| Lead guitarist's output | 27 |
| Lead guitarist, often | 21 |
| Lead guitarists often play them | 31 |
| Lead has one | 12 |
| Lead head? | 10 |
| Lead in | 7 |
| Lead in The Heiress | 22 |
| Lead in "Shane" | 25 |
| Lead in the theater? | 20 |
| Lead in to stream or riff | 25 |
| Lead into temptation | 20 |
| Lead investigator?: Abbr. | 25 |
| Lead lead, in Clue | 18 |
| Lead lines? | 11 |
| Lead male descriptor | 20 |
| Lead male or female | 19 |
| Lead monitor, for short | 23 |
| Lead off | 8 |
| Lead on | 7 |
| Lead on a court | 15 |
| Lead on Broadway | 16 |
| Lead or bit | 11 |
| Lead or cameo | 13 |
| Lead or copper, e.g. | 20 |
| Lead or eyebrow | 15 |
| Lead or heavy | 13 |
| Lead or zinc | 12 |
| Lead ore | 8 |
| Lead ore samples | 16 |
| Lead ores | 9 |
| Lead parts | 10 |
| Lead pellet-filled item used to weigh down scuba divers | 55 |
| Lead performer | 14 |
| Lead pilot's helper | 23 |
| Lead pilot's support | 24 |
| Lead plant | 10 |
| Lead player | 11 |
| Lead provider | 13 |
| Lead pumper | 11 |
| Lead pumper, in old slang | 25 |
| Lead rat in "Ratatouille" | 35 |
| Lead reducer | 12 |
| Lead role | 9 |
| Lead role in 'La Cage aux Folles' | 41 |
| Lead role in "A Chorus Line" | 38 |
| Lead role in "Clueless" | 33 |
| Lead role in "Die Meistersinger von Nürnberg" | 58 |
| Lead role in "Hawaii Five-O" | 38 |
| Lead role in "La Cage aux Folles" | 43 |
| Lead role in "Miracle on 34th Street" | 47 |
| Lead role in "The Piano" | 34 |
| Lead role in "The Vampire Diaries" | 44 |
| Lead role in a 1924 G.B. Shaw play | 34 |