| Major rd. in Philly or San Francisco | 36 |
| Major purchaser of McCain ads: Abbr. | 36 |
| Major publisher of romance novels | 33 |
| Major portion of oneÂ’s grade, often | 39 |
| Major player on '70s and '80s TV | 40 |
| Major piece of cribbage equipment | 33 |
| Major part of sumo wrestlin'? | 33 |
| Major org. representing entertainers and athletes | 49 |
| Major of many a poli sci student | 32 |
| Major New York-to-Tennessee route | 33 |
| Major movie on a studio's schedule | 38 |
| Major mix-up in the margarine case? | 35 |
| Major Mexican drug cartel, with "los" | 47 |
| Major lobbyist against generic drugs | 36 |
| Major leagues, slangily, with "the" | 45 |
| Major leagues, in baseball slang | 32 |
| Major leagues, in baseball lingo | 32 |
| Major leaguer who played in parts of five decades | 49 |
| Major leaguer or golf instructor | 32 |
| Major leaguer in orange and black | 33 |
| Major League player before moving to S.F. | 41 |
| Major League Baseball's oldest rookie ever | 46 |
| Major League Baseball family name | 33 |
| Major League Baseball commissioner Bud | 38 |
| Major League Baseball commissioner | 34 |
| Major irritant for American colonists | 37 |
| Major Internet service provider, for short | 42 |
| Major influence in '60s music | 33 |
| Major industrial center near Manchester | 39 |
| Major Hoople's outburst, in old comics | 42 |
| Major Hoople's exclamation, in the comics | 45 |
| Major Hoople's "whoops" | 37 |
| Major Hoople's "drat" | 35 |
| Major highway from Fla. to Calif. | 33 |
| Major govt.-owned power producer | 32 |
| Major gold-mining area, with "the" | 44 |
| Major German river, to a Frenchman | 34 |
| Major French publisher of reference works | 41 |
| Major figure in "Paradise Lost" | 41 |
| Major factor in Korean independence | 35 |
| Major exporter of handmade carpets | 34 |
| Major export of Brazil and Australia | 36 |
| Major export of Albania and South Africa | 40 |
| Major export from the islets of Langerhans | 42 |
| Major divisions of geological time | 34 |
| Major division of geological time | 33 |
| Major digital satellite service provider | 40 |
| Major country with the longest life expectancy | 46 |
| Major component of the euro symbol | 34 |
| Major component of Saturn's rings | 37 |
| Major component of kidney stones | 32 |
| Major company in metallic products | 34 |
| Major college football's winningest coach | 45 |
| Major city off the coast of China | 33 |
| Major city of southwest Colombia | 32 |
| Major chunk of Earth's surface | 34 |
| Major Chicago tourist attraction | 32 |
| Major Côte d'Ivoire export | 33 |
| Major Canadian short-story writer | 33 |
| Major brand in heating and air conditioning | 43 |
| Major Baroque composer's signature | 38 |
| Major Baroque composer's monogram | 37 |
| Major artery through San Antonio | 32 |
| Major ancient construction project | 34 |
| Major African humanitarian concern of the 2000s | 47 |
| Major Adams of "Wagon Train" and others | 49 |
| Majestic animal at the Grand Canyon | 35 |
| Maj. with credits for studying credit | 37 |
| Maj. Winchester portrayer on "MASH" | 45 |
| Maj. metropolis of the Show-Me State | 36 |
| Maj. Houlihan portrayer in "MASH" | 43 |
| Maintains the machinery, in a way | 33 |
| Maintains one's subscription | 32 |
| Maintaining shoe gloss, in a way | 32 |
| Maintaining one's composure, say | 36 |
| Maintaining a constant temperature | 34 |
| Maintainers of a sacred flame in ancient Rome | 45 |
| Maintained, as one's principles | 35 |
| Maintain vital info on actor Rob? | 33 |
| Maintain surveillance of a feudal manor? | 40 |
| Maintain one's credit rating? | 33 |
| Maintain one's credit rating | 32 |
| Maintain a static state of readiness | 36 |
| Mainland Europe's westernmost capital | 41 |
| Mainland Africa's smallest nation | 37 |
| Maine travel agency's come-on? | 34 |
| Maine town named for a Penobscot chief | 38 |
| Maine senator with a climate-appropriate name | 45 |
| Maine river explored by Champlain | 33 |
| Maine motto ("I direct") | 34 |
| Main, Hollywood and Vine (Abbr.) | 32 |
| Main thoroughfare through N.Y.C.'s Chinatown | 48 |
| Main route on the main (with an up-front charge) | 48 |
| Main role on "My Big Fat Greek Life" | 46 |
| Main rat in "Ratatouille" | 35 |
| Main port for grain from the Ukraine | 36 |
| Main part of a church's interior | 36 |
| Main job of bored em¬ploy¬ees? | 36 |
| Main international airport of Japan | 35 |
| Main ingredients in hasenpfeffer | 32 |