| Large sea ducks | 15 |
| Large sea ray | 13 |
| Large sea snail | 15 |
| Large sea snails | 16 |
| Large sea turtles | 17 |
| Large seabird | 13 |
| Large seabirds | 14 |
| Large search area | 17 |
| Large seaweed | 13 |
| Large section in an atlas | 25 |
| Large seed of the alligator pear | 32 |
| Large separation | 16 |
| Large series, as of tests | 25 |
| Large server | 12 |
| Large serving bowl | 18 |
| Large serving bowls | 19 |
| Large serving dishes | 20 |
| Large shade tree | 16 |
| Large shark | 11 |
| Large sharks | 12 |
| Large ship | 10 |
| Large shoe size | 15 |
| Large shoe specification | 24 |
| Large shoe width | 16 |
| Large shrimp | 12 |
| Large shrimp sauteed in oil | 27 |
| Large Sicilian volcano | 22 |
| Large silvery fish | 18 |
| Large single-edged knives | 25 |
| Large sizes, briefly | 20 |
| Large slice | 11 |
| Large slices | 12 |
| Large slipknots | 15 |
| Large sloths | 12 |
| Large snail | 11 |
| Large snake | 11 |
| Large snake mackerel | 20 |
| Large snake or James Clavell best seller | 40 |
| Large social gathering, e.g. | 28 |
| Large societal group | 20 |
| Large sofas | 11 |
| Large software manufacturer | 27 |
| Large soup dish | 15 |
| Large source of income in Fla. | 30 |
| Large South African antelope | 31 |
| Large southern constellation | 28 |
| Large Spanish ships of old | 26 |
| Large species of deer | 21 |
| Large spiral shell | 18 |
| Large spoon | 11 |
| Large sport fish | 16 |
| Large sports structure | 22 |
| Large spotted cats | 18 |
| Large spread | 12 |
| Large spreads | 13 |
| Large stack | 11 |
| Large stadium | 13 |
| Large stain | 11 |
| Large stake | 11 |
| Large star in Lyra | 18 |
| Large star in Virgo | 19 |
| Large stash of cash | 19 |
| Large steamship | 15 |
| Large stein | 11 |
| Large Steinways | 15 |
| Large step | 10 |
| Large steps | 11 |
| Large stock transactions involving deadbolt securities? | 55 |
| Large storage container | 23 |
| Large stores | 12 |
| Large stove | 11 |
| Large string instrument | 23 |
| Large string instruments | 24 |
| Large stringed instrument | 25 |
| Large strings | 13 |
| Large structure for racing | 26 |
| Large studio lamp | 17 |
| Large subfamily of Indo-European languages | 42 |
| Large sum in India | 18 |
| Large sum, slangily | 19 |
| Large sums of money | 19 |
| Large sums, as of money | 23 |
| Large supply | 12 |
| Large supply of anything | 24 |
| Large swallow | 13 |
| Large swallows | 14 |
| Large swine | 11 |
| Large system of newsgroups | 26 |
| Large tangelo | 13 |
| Large tank | 10 |
| Large tank forces | 17 |
| Large tanks | 11 |
| Large tanks for marine life | 27 |
| Large tawny feline | 18 |
| Large terrier | 13 |
| Large terriers | 14 |
| Large theatre | 13 |
| Large thing that takes years to mature | 38 |
| Large time piece? | 17 |
| Large timeline segment | 22 |