| ___ Sea (Amu Darya's outlet) | 32 |
| ___ Sea (a big lake) | 20 |
| ___ Sea | 7 |
| ___ Se (NYC Michelin three-star restaurant) | 43 |
| ___ se (intrinsically) | 22 |
| ___ se | 6 |
| ___ Sculptoris, southern constellation | 38 |
| ___ Scrolls | 11 |
| ___ scripta (statute) | 21 |
| ___ screen (lab test) | 21 |
| ___ scream therapy | 18 |
| ___ Scowcroft, former presidential adviser | 42 |
| ___ scout | 9 |
| ___ Scotus, Scottish theologian | 31 |
| ___ Scott-Heron ("The Revolution Will Not Be Televised" poet) | 71 |
| ___ Scott, noted slave | 22 |
| ___ Scott v. Sandford | 21 |
| ___ Scott decision, 1857 | 24 |
| ___ Scott Decision (1857) | 25 |
| ___ Scott decision | 18 |
| ___ Scott case | 14 |
| ___ Scott Card, "Ender's Game" writer | 51 |
| ___ Scott | 9 |
| ___ Scotland Yard | 17 |
| ___ Scotia, Canada | 18 |
| ___ Scotia | 10 |
| ___ score (retaliate) | 21 |
| ___ score | 9 |
| ___ Scilly | 10 |
| ___ Science Fiction & Fact (magazine) | 41 |
| ___ sci: college major | 22 |
| ___ sci. | 8 |
| ___ sci (college major, informally) | 35 |
| ___ sci (college major) | 23 |
| ___ Sci (college dept.) | 23 |
| ___ sci (coll. major) | 21 |
| ___ sci | 7 |
| ___ Schwarz (toy store) | 23 |
| ___ Schwarz (toy retailer) | 26 |
| ___ Schwarz (toy company) | 25 |
| ___ Schwarz (noted N.Y. toy store) | 34 |
| ___ Schwarz | 11 |
| ___ Schwartz | 12 |
| ___ Schreiber (headliner of TV's "Ray Donovan") | 61 |
| ___ school: Abbr. | 17 |
| ___ school (precollege institution) | 35 |
| ___ school (pre-college institution) | 36 |
| ___ School (early 20th-century art group) | 41 |
| ___ school (doctor's training) | 34 |
| ___ School (20th-century art group) | 35 |
| ___ school | 10 |
| ___ scholar | 11 |
| ___ schnitzel | 13 |
| ___ Schneider, villainess in "Indiana Jones and the Last Crusade" | 75 |
| ___ scheme (investment swindle) | 31 |
| ___ scheme (investment scam) | 28 |
| ___ scheme (investment fraud) | 29 |
| ___ scheme (eponymous investment scam) | 38 |
| ___ scheme | 10 |
| ___ Schary | 10 |
| ___ sch. | 8 |
| ___ scarum | 10 |
| ___ scan (diagnostic aid) | 25 |
| ___ scan (biometric authentication method) | 42 |
| ___ scan | 8 |
| ___ scampi | 10 |
| ___ Scamander, pseudonym of J. K. Rowling | 41 |
| ___ scaloppini | 14 |
| ___ scaloppine | 14 |
| ___ scallopini | 14 |
| ___ scale of mineral hardness | 29 |
| ___ scale (mineral hardness measure) | 36 |
| ___ scale (hardness measure) | 28 |
| ___ scale (earthquake measurer) | 31 |
| ___ scale | 9 |
| ___ Sánchez, co-director of "The Blair Witch Project" | 66 |
| ___ Says! (dog treats) | 22 |
| ___ says (tots' game) | 25 |
| ___ Says (kids' game) | 25 |
| ___ Says (child's game) | 27 |
| ___ say die | 11 |
| ___ say (unfortunately) | 23 |
| ___ say (unfortunate) | 21 |
| ___ say (seemingly) | 19 |
| ___ say | 7 |
| ___ saxophone | 13 |
| ___ sax (low wind) | 18 |
| ___ sax | 7 |
| ___ Sawyer | 10 |
| ___ saw (carpenter's curve cutter) | 38 |
| ___ Savy Fav (New York City indie band) | 39 |
| ___ Savahl (couture label) | 26 |
| ___ Savage, player of the boy on "Boy Meets World" | 60 |
| ___ sausage | 11 |
| ___ Sauk Mountain, Mo. | 22 |
| ___ Sauer handguns | 18 |
| ___ Sauer | 9 |
| ___ Saud, founder of Saudi Arabia | 33 |
| ___ Saud (Saudi Arabia's founder) | 37 |
| ___ Saud (former Saudi king) | 28 |