| What Scots speak | 16 |
| What Scopes taught | 18 |
| What scientists working for Gatorade have? | 42 |
| What scientists use to predict the rates of chemical reactions | 62 |
| What science fiction writers do | 31 |
| What science fiction movie do taxes and amine bring to mind? | 60 |
| What sci-fi heroes must combat | 30 |
| What Schwarzenegger pumps | 25 |
| What schools in the same district have, often | 45 |
| What schools have | 17 |
| What schlimazels usually do | 27 |
| What scattered things are said to be all over | 45 |
| What Scarlett did? | 18 |
| What scammers practice | 22 |
| What says "Miss America" on Miss America | 50 |
| What say? | 9 |
| What savers do with money | 25 |
| What savants are steeped in | 27 |
| What saunas feature | 19 |
| What sauerkraut ferments in | 27 |
| What satiety sans variety breeds | 32 |
| What Satchmo said to Dolly | 26 |
| What Satan sows | 15 |
| What Satan gets from poison ivy? | 32 |
| What Satan asked | 16 |
| What sassafras has a lot of? | 28 |
| What SASEs are | 14 |
| What Sartre said? | 17 |
| What santé means | 19 |
| What Santana was doing on '81 hit | 37 |
| What Santa's reindeer shouted out with? | 43 |
| What Santa's making (and checking twice) | 44 |
| What Santa's mail consists of | 33 |
| What Santa's elves rode when the sleigh broke down? | 55 |
| What Santa's doing | 22 |
| What Santa makes | 16 |
| What Santa is not | 17 |
| What Santa gets for climbing down the chimney? | 46 |
| What Santa Claus is | 19 |
| What Santa checks twice | 23 |
| What Sandy says | 15 |
| What Sandburg called "a bucket of ashes" | 50 |
| What Sampras does? | 18 |
| What Samantha twitched on "Bewitched" | 47 |
| What Sam twitched on "Bewitched" | 42 |
| What Sam plays in "Casablanca" | 40 |
| What Sam made too long | 22 |
| What Sam Goldwyn said to "include me in" | 50 |
| What salt may be used as | 24 |
| What salmon seek to do | 22 |
| What salmon do upriver | 22 |
| What salmon do | 14 |
| What Salk vaccine prevents | 26 |
| What Salk conquered | 19 |
| What salesmen proffer | 21 |
| What sales reps may be reimbursed for | 37 |
| What salads may be tossed in | 28 |
| What sailors call skiffs | 24 |
| What sachets impart | 19 |
| What S. Johnson called "the last refuge of a scoundrel" | 65 |
| What S. B. Anthony wanted | 25 |
| What S O S signifies | 20 |
| What S & L's do | 23 |
| What ruthless people show | 25 |
| What Ruth was to Gehrig | 23 |
| What Ruth was sultan of | 23 |
| What Ruth forgot to bring to pool night? | 40 |
| What runs ruin | 14 |
| What running mates do? | 22 |
| What runners and locomotives "get up" | 47 |
| What Rumpole wears | 18 |
| What rumors make | 16 |
| What rules are, essentially | 27 |
| What rulers hold | 16 |
| What Rudolph's nose does | 28 |
| What Roy Rogers had with dinner? | 32 |
| What rowdy concergoer will do | 29 |
| What roustabouts put up | 23 |
| What Roscoe Orman of "Sesame Street" played in 1974's "Willie Dynamite" | 95 |
| What roots connect to | 21 |
| What Roosevelt and Truman were | 30 |
| What rookies need to learn | 26 |
| What rookies must learn | 23 |
| What rookies are shown, with "the" | 44 |
| What Ronnie Wood uses in downtime | 33 |
| What Romeo compared Juliet to | 29 |
| What Romeo calls Juliet | 23 |
| What Romeo and Juliet planned to do | 35 |
| What Romeo and Juliet had to do? | 32 |
| What Romeo and Juliet did | 25 |
| What rolling stones don't gather | 36 |
| What roll calls count | 21 |
| What rodeo horses do | 20 |
| What rodents do | 15 |
| What Rod Carew wields | 21 |
| What Rocky sparred with | 23 |
| What rockers' car windows have | 34 |
| What rockers leave for tour | 27 |
| What rocker's live-in chef provides | 39 |
| What rocker will do at hotel, post-show | 39 |