| Last Supper guests | 18 |
| Last Supper guest | 17 |
| Last Supper figure | 18 |
| Last Supper diners | 18 |
| Last Supper diner | 17 |
| Last Supper depiction | 21 |
| Last Supper cup | 15 |
| Last Supper count | 17 |
| Last Supper chalice | 19 |
| Last Supper attendees | 21 |
| Last Supper attendee | 20 |
| Last Supper | 11 |
| Last Stuart ruler | 17 |
| Last Stuart queen | 17 |
| Last Stuart of the monarchy | 27 |
| Last Stuart monarch | 19 |
| Last strike at Skydome? | 23 |
| Last straw | 10 |
| Last story in J.D. Salinger's "Nine Stories" | 58 |
| Last stops | 10 |
| Last stop on a diamond | 22 |
| Last stop before home? | 22 |
| Last stop before home | 21 |
| Last stop | 9 |
| Last step in cleaning | 21 |
| Last step before the majors | 27 |
| Last step at a bakery | 21 |
| Last state admitted in the 1800s | 32 |
| Last stands? | 12 |
| Last stand? | 11 |
| Last stand of 1836 | 18 |
| Last stand for Travis and Bowie | 31 |
| Last stand for Bowie | 20 |
| Last stage of strategy, in chess | 32 |
| Last stage of some lives | 24 |
| Last stage of insect development | 32 |
| Last stage | 10 |
| Last speaker in many an old cartoon | 35 |
| Last Spanish king before Juan Carlos | 36 |
| Last Soviet first lady | 22 |
| Last sound some bugs hear? | 26 |
| Last sound some bugs hear | 25 |
| Last sound of work | 18 |
| Last song? | 10 |
| Last song Rodgers and Hammerstein did together (1959) | 53 |
| Last song recorded by the Beatles | 33 |
| Last song on Led Zeppelin's "Houses of The Holy" | 62 |
| Last song on "OK Computer," with "The" | 58 |
| Last song in a show | 19 |
| Last song heard on Disneyland's Splash Mountain | 51 |
| Last slice of bread | 19 |
| Last six lines of poetry | 24 |
| Last six lines of a sonnet, often | 33 |
| Last six lines of a sonnet | 26 |
| Last six lines of a Petrarchan sonnet | 37 |
| Last sip bits | 13 |
| Last single-digit number | 24 |
| Last single statement? | 22 |
| Last single statement | 21 |
| Last single digit | 17 |
| Last single blasts? | 19 |
| Last sign | 9 |
| Last sight for Lot's wife | 29 |
| Last shot? | 10 |
| Last shogunate capital | 22 |
| Last several notes | 18 |
| Last section of the OED | 23 |
| Last section of a London telephone directory | 44 |
| Last Russian czarina | 20 |
| Last ruling Stuart | 18 |
| Last ruler of the Ptolemaic dynasty, informally | 47 |
| Last ruler of the Julio-Claudian dynasty | 40 |
| Last royal governor of Mass. | 28 |
| Last row's view | 19 |
| Last row in the balcony? | 24 |
| Last roundup? | 13 |
| Last round, usually | 19 |
| Last river to cross? | 20 |
| Last rites in some religious movements | 38 |
| Last ride? | 10 |
| Last ride autos | 15 |
| Last rewards? | 13 |
| Last review? | 12 |
| Last resort? | 12 |
| Last resort, sometimes | 22 |
| Last resort, perhaps | 20 |
| Last resort, in some sci-fi films | 33 |
| Last resort in poker, often | 27 |
| Last resort actions | 19 |
| Last request, part 1 | 20 |
| Last report on the evening news, typically | 42 |
| Last remaining part | 19 |
| Last reliever called | 20 |
| Last rehearsal | 14 |
| Last refuge for a scoundrel? | 28 |
| Last question in this puzzle | 28 |
| Last queen of Spain | 19 |
| Last queen before Sofia | 23 |
| Last quarter | 12 |
| Last Quaker president | 21 |