| Middle of the afternoon, in Milan | 33 |
| Middle of the "Able... Elba" palindrome | 49 |
| Middle of some arithmetic advice | 32 |
| Middle of nowhere, metaphorically | 33 |
| Middle of Fred Flintstone's shout | 37 |
| Middle of Descartes' conclusion | 35 |
| Middle of Byron's famous trio | 33 |
| Middle of an old children's trio | 36 |
| Middle of a well-known palindrome | 33 |
| Middle of a well-known Kipling trio | 35 |
| Middle of a thought-provoking quip | 34 |
| Middle of a quip from a frustrated user? | 40 |
| Middle of a psychologist's statement | 40 |
| Middle of a patriotic sports trio | 33 |
| Middle of a paper and pencil game | 33 |
| Middle of a palindrome re Napoleon | 34 |
| Middle of a New Year's song title | 37 |
| Middle of a Napoleonic palindrome | 33 |
| Middle of a Michelangelo Antonioni film trilogy | 47 |
| Middle of a Fred Flintstone shout | 33 |
| Middle of a clumsy alpinist's quip | 38 |
| Middle of a "Flintstones" exclamation | 47 |
| Middle of 'Acquaintance' definition | 43 |
| Middle number of three measurements | 35 |
| Middle name on a 2010 Technical Grammy | 38 |
| Middle name on 1,093 U.S. patents | 33 |
| Middle name of Thomas Edison and Dick Cavett | 44 |
| Middle name of the 21st U.S. President | 38 |
| Middle name of Sen. Joe Lieberman | 33 |
| Middle name of President Garfield | 33 |
| Middle name of Lenin or Tchaikovsky | 35 |
| Middle name of Lady Bird Johnson | 32 |
| Middle name of Chan's creator | 33 |
| Middle name of a July 16, 1992, dropout | 39 |
| Middle name of a "Wizard" | 35 |
| Middle name of 20th U.S. president | 34 |
| Middle name of "The King" | 35 |
| Middle name of ''The King'' | 43 |
| Middle name adopted by John Lennon | 34 |
| Middle name accidentally given to No. 18 | 40 |
| Middle management protocol, for short | 37 |
| Middle flipper of a lobster's tail | 38 |
| Middle facial mark, in Massachusetts? | 37 |
| Middle Easterners named for their first sultan | 46 |
| Middle Eastern port on its own gulf | 35 |
| Middle Eastern org. founded in 1964 | 35 |
| Middle Eastern muck-a-muck (Var.) | 33 |
| Middle Eastern king deposed in 1964 | 35 |
| Middle Eastern independence seeker | 34 |
| Middle Eastern football competition? | 36 |
| Middle Eastern federation, briefly | 34 |
| Middle Eastern country on the Red Sea | 37 |
| Middle Eastern capital since 1788 | 33 |
| Middle Eastern capital once called Philadelphia | 47 |
| Middle East state ruled by the al Thani family | 46 |
| Middle East leader raised in Milwaukee | 38 |
| Middle East import frequently put under sanctions | 49 |
| Middle East group with observer status in the UN | 48 |
| Middle East carrier with a blue and white flag | 46 |
| Middle daughter on "Downton Abbey" | 44 |
| Middle class resident, in the Middle Ages | 41 |
| Middle brother in a 2000s pop trio | 34 |
| Middle America symbol of 2008 politics | 38 |
| Mid-sixth century Chinese dynasty | 33 |
| Mid-procedure command from Frankenstein to Igor? | 48 |
| Mid-perm phone call's result? | 33 |
| Mid-February salutation, perhaps | 32 |
| Mid-century presidential nickname | 33 |
| Mid-century filling option in the mid-Atlantic | 46 |
| Mid-Atlantic nickname, with "The" | 43 |
| Mid-Atlantic border town portmanteau | 36 |
| Mid-20th-century Chinese premier | 32 |
| Mid-'70s David Bowie alter ego | 34 |
| Mid-'40s World No. 1 tennis pro Bobby | 41 |
| Microwave, to a cup of cool Earl Grey | 37 |
| Microwave popcorn brand with a movie themed name | 48 |
| Microwave clock display, briefly | 32 |
| Microsoft's head, to his employees | 38 |
| Microsoft's erstwhile encyclopedia | 38 |
| Microsoft's chief executive Ballmer | 39 |
| Microsoft's answer to the iPod | 34 |
| Microsoft Works, according to some | 34 |
| Microsoft product sounded really big? (5) | 41 |
| Microsoft product launched in 2001 | 34 |
| Microsoft product introduced in 2001 | 36 |
| Microscopist's sighting (Var.) | 34 |
| Microscopic Dr. Seuss characters | 32 |
| Microscopic crime scene clue, briefly | 37 |
| Microscopic animal that swims with whirling cilia | 49 |
| Microscope slide creature (Var.) | 32 |
| Microprogram stored in a computer's ROM | 43 |
| Microphone inventor's initials | 34 |
| Micronesian nation once called Pleasant Island | 46 |
| Micronesian locale uninhabited for over 50 years | 48 |
| Microcomputer's stronger kin | 32 |
| Microbiologist with a Congressional Gold Medal | 46 |
| Microbiologist spread some gossip? | 34 |
| Mickey, when singing "M-I-C, K-E-Y..."? | 49 |
| Mickey's mouth or greatest fear | 35 |
| Mickey's costar in "The Wrestler" | 47 |