| It's typically off base | 27 |
| It's typically played indoors | 33 |
| It's typically slow during rush hour | 40 |
| It's typically ten percent | 30 |
| It's typically thrown eight feet | 36 |
| It's ultimate | 17 |
| It's un-PC | 14 |
| It's unacceptable | 21 |
| It's unaccompanied in church | 32 |
| It's unavoidable | 20 |
| It's unbelievable | 21 |
| It's uncertain when it's gray | 37 |
| It's uncomfortable to be on it | 34 |
| It's uncultivated | 21 |
| It's undefined | 18 |
| It's undeliverable | 22 |
| It's undeliverable and unreturnable | 39 |
| It's undeniable | 19 |
| It's under a canine's coat | 34 |
| It's under a car's hood | 31 |
| It's under a cup | 20 |
| It's under a foot | 21 |
| It's under a toddler's Band-Aid | 39 |
| It's under a top | 20 |
| It's under an eyeglass frame | 32 |
| It's under an underscore | 28 |
| It's under cover | 20 |
| It's under foot | 19 |
| It's under imperial dominion | 32 |
| It's under Italy's boot | 31 |
| It's under krypton on the periodic table | 44 |
| It's under layers | 21 |
| It's under pressure | 23 |
| It's under Tenn. | 20 |
| It's under the boardwalk | 28 |
| It's under the conjunctiva | 30 |
| It's under the Host | 23 |
| It's under the Pont Neuf | 28 |
| It's under the Ponte Vecchio | 32 |
| It's under the roof | 23 |
| It's under Wayne Manor | 26 |
| It's under wraps | 20 |
| It's underfoot | 18 |
| It's underfoot! | 19 |
| It's underground | 20 |
| It's undeveloped | 20 |
| It's unfair | 15 |
| It's unfathomable | 21 |
| It's unfortunate | 20 |
| It's unhealthy to draw on, briefly | 38 |
| It's unhealthy to hold one | 30 |
| It's unidentified, usually | 30 |
| It's unique | 15 |
| It's universal, in Chinese philosophy | 41 |
| It's unlikely to air on PBS | 31 |
| It's unlikely to be realized | 32 |
| It's unlikely to be shot on a lot | 37 |
| It's unlikely to make a chicken move | 40 |
| It's unlikely to work | 25 |
| It's unlikely to yield results | 34 |
| It's unmetered | 18 |
| It's unpleasant to be in | 28 |
| It's unpleasant to end on one | 33 |
| It's unpleasant when things end on one | 42 |
| It's unreal | 15 |
| It's unresolved | 19 |
| It's unsettling to be out of them | 37 |
| It's unsmelted | 18 |
| It's untidy | 15 |
| It's unvarnished | 20 |
| It's up all night at camp | 29 |
| It's up all night at camp? | 30 |
| It's up for auction | 23 |
| It's up for bid | 19 |
| It's up for discussion | 26 |
| It's up for grabs every six years | 37 |
| It's up for grabs every two years | 37 |
| It's up for grabs on a court | 32 |
| It's up in the air | 22 |
| It's up in the air? | 23 |
| It's up over 1000% since 1960: Abbr. | 40 |
| It's up the coast from Napoli | 33 |
| It's up there | 17 |
| It's up to you | 18 |
| It's up when you're angry | 33 |
| It's up your sleeve | 23 |
| It's uphill all the way | 27 |
| It's uplifting | 18 |
| It's uplifting to a schusser | 32 |
| It's uplifting to a skier | 29 |
| It's upped at times | 23 |
| It's upstream from Luxor | 28 |
| It's urged by NOW | 21 |
| It's used at Gallaudet U. | 29 |
| It's used between periods | 29 |
| It's used but not owned | 27 |
| It's used by many a junior spy | 34 |
| It's used by people who suck | 32 |
| It's used by some who miss the mark? | 40 |
| It's used during an introductory course | 43 |