| It's sometimes smoked in Sweden | 35 |
| It's sometimes sold in bags | 31 |
| It's sometimes stolen | 25 |
| It's sometimes strapless | 28 |
| It's sometimes struck | 25 |
| It's sometimes struck in photography | 40 |
| It's sometimes stubbed | 26 |
| It's sometimes studied in a lab | 35 |
| It's sometimes the word | 27 |
| It's sometimes thrown on the court | 38 |
| It's sometimes wild | 23 |
| It's sometimes winkin' or blinkin,' but doesn't nod | 67 |
| It's sometimes wrapped in rice | 34 |
| It's sometimes written in the sand | 38 |
| It's sometimes written with a colon | 39 |
| It's somewhat less than a pound | 35 |
| It's somewhat near here | 27 |
| It's somewhat stronger than LOL | 35 |
| It's somewhere in the neighborhood: Abbr. | 45 |
| It's soothed by music, perhaps | 34 |
| It's soothing | 17 |
| It's sought after in Washington | 35 |
| It's sought by conquistadores | 33 |
| It's sought by crunchers | 28 |
| It's sought in hot weather | 30 |
| It's sought in vein | 23 |
| It's sought in Washington | 29 |
| It's sought-after in Hollywood | 34 |
| It's sour | 13 |
| It's south of a hip joint | 29 |
| It's south of ancient Shiloh | 32 |
| It's south of Borneo | 24 |
| It's south of Brigham City | 30 |
| It's south of Can. | 22 |
| It's south of Canada | 24 |
| It's south of Canis Major | 29 |
| It's south of Eur. | 22 |
| It's south of Florida | 25 |
| It's south of Georgia | 25 |
| It's south of Georgia? | 26 |
| It's south of Helsinki | 26 |
| It's south of Ky. | 21 |
| It's south of Lillehammer | 29 |
| It's south of Mason City on I-35 | 36 |
| It's south of Mass. | 23 |
| It's south of Minnesota | 27 |
| It's south of S. Dak | 24 |
| It's south of S.D. | 22 |
| It's south of San Diego | 27 |
| It's south of Sask. | 23 |
| It's south of Saudi Arabia | 30 |
| It's south of Scorpio's tail | 36 |
| It's south of Scorpius | 26 |
| It's south of Scot. | 23 |
| It's south of Siberia | 25 |
| It's south of Sicily | 24 |
| It's south of Sonoma | 24 |
| It's south of Sp. | 21 |
| It's south of the Banda Sea | 31 |
| It's south of the Bass Strait | 33 |
| It's south of the Caspian | 29 |
| It's south of the Caucasus | 30 |
| It's south of the Pyrenees | 30 |
| It's south of the Sahara | 28 |
| It's south of the U.S. | 26 |
| It's south of the Yucatán | 32 |
| It's south of Va. | 21 |
| It's south of Vesuvius | 26 |
| It's south of Wash. | 23 |
| It's south of West Palm | 27 |
| It's south-southeast of Cleveland | 37 |
| It's southeast of New Delhi | 31 |
| It's southeast of Rome | 26 |
| It's southeast of Scottsdale | 32 |
| It's southwest of Bologna | 29 |
| It's southwest of Daytona Beach | 35 |
| It's sown and grown | 23 |
| It's spent away from everyone else | 38 |
| It's spent in Asia | 22 |
| It's spent in Istanbul | 26 |
| It's spent in Spain | 23 |
| It's spent in Trent | 23 |
| It's spent on the Riviera | 29 |
| It's splintered | 19 |
| It's split | 14 |
| It's split in a lab | 23 |
| It's split in soups | 23 |
| It's split into eras | 24 |
| It's spoken from the hip? | 29 |
| It's spoken in Berlin (Abbr.) | 33 |
| It's spoken in chop shops? | 30 |
| It's spoken in Islamabad | 28 |
| It's spoken in Karachi | 26 |
| It's spoken in Kuala Lumpur | 31 |
| It's spoken in los Estados Unidos | 37 |
| It's spoken in Stornoway | 28 |
| It's spoken in Vientiane | 28 |
| It's spoken on Bering Island | 32 |
| It's sportier than a sedan | 30 |
| It's spotted at a casino | 28 |