| It stretches from Maine to Florida | 34 |
| It stretches from the Atlantic to the Pacific | 45 |
| It strikes the ball | 19 |
| It strives underground | 22 |
| It struck F.D.R. in 1921 | 24 |
| It sublimes at -109.26°F | 27 |
| It succeeded "Let It Be" as Billboard's #1 single | 63 |
| It sucks | 8 |
| It suggests a response | 22 |
| It suggests the vowel pattern in the five starred answers | 57 |
| It suits you | 12 |
| It summons doctors prematurely? | 31 |
| It supplies drivers | 19 |
| It supports 32 "men" | 30 |
| It supports spectacles | 22 |
| It supports the cast | 20 |
| It supports the spinal column | 29 |
| It supports women | 17 |
| It surrounds a house | 20 |
| It surrounds a lens | 19 |
| It surrounds a pit | 18 |
| It surrounds Città del Vaticano | 34 |
| It surrounds Lesotho | 20 |
| It surrounds Lesotho: Abbr. | 27 |
| It surrounds Paros | 18 |
| It surrounds San Marino | 23 |
| It surrounds St.-Pierre | 23 |
| It surrounds the Isle of Man | 28 |
| It surrounds the Parthenon | 26 |
| It surrounds the pupil | 22 |
| It surrounds the puzzles' long answers | 42 |
| It surrounds the Vatican | 24 |
| It survived the crashing rocks, in myth | 39 |
| It swallowed Amittai's son: Jonah 1:17 | 42 |
| It sweeps across the face | 25 |
| It swims in a fur | 17 |
| It swings between trees | 23 |
| It swings in the mouth | 22 |
| It takes a beating | 18 |
| It takes a beating during a beer bash | 37 |
| It takes a big bow | 18 |
| It takes a bow | 14 |
| It takes a bow at a musical performance | 39 |
| It takes a bow at a recital | 27 |
| It takes a bow in an orchestra | 30 |
| It takes a few years to mature | 30 |
| It takes a hammering | 20 |
| It takes a licking | 18 |
| It takes a licking and keeps on ticking | 39 |
| It takes a light, for short | 27 |
| It takes a lot of eggs | 22 |
| It takes a lot to get one upset | 31 |
| It takes a nice drive | 21 |
| It takes a paddling | 19 |
| It takes a pasting | 18 |
| It takes a picture | 18 |
| It takes a second to be one | 27 |
| It takes a toll: Abbr. | 22 |
| It takes a while to tell | 24 |
| It takes a year to get around him | 33 |
| It takes an ID to get mail there | 32 |
| It takes balls | 14 |
| It takes brains to crack it | 27 |
| It takes checks and gives balances | 34 |
| It takes control after a coup d'etat | 40 |
| It takes figuring | 17 |
| It takes folks in | 17 |
| It takes forever | 16 |
| It takes four jokers to play it | 31 |
| It takes four to walk | 21 |
| It takes grubs for grub | 23 |
| It takes in the sights | 22 |
| It takes night deposits | 23 |
| It takes off a lot | 18 |
| It takes off at night | 21 |
| It takes off but can't fly | 30 |
| It takes panes | 14 |
| It takes place in the dark | 26 |
| It takes quite a while to tell | 30 |
| It takes seconds | 16 |
| It takes tending | 16 |
| It takes the cake | 17 |
| It takes the shape of a double helix | 36 |
| It takes things to extremes | 27 |
| It takes things to the extreme | 30 |
| It takes three tricks to get a hand | 35 |
| It takes thyme | 14 |
| It takes time | 13 |
| It takes time to cure | 21 |
| It takes time to settle them | 28 |
| It takes turns | 14 |
| It takes two | 12 |
| It takes two for this | 21 |
| It takes two nuts | 17 |
| It takes two people to tie it | 29 |
| It takes two to . . . | 21 |
| It takes two to be jolly | 24 |
| It takes two to do it | 21 |
| It takes two to do this | 23 |
| It takes two to make eleven | 27 |