| It runs through Venus | 21 |
| It runs two different ways | 26 |
| It runs up trees | 16 |
| It runs when broken | 19 |
| It runs when caught | 19 |
| It runs when you pass | 21 |
| It runs while you ride | 22 |
| It saddens SADD | 15 |
| It sailed between the Cyanean rocks | 35 |
| It sailed for about five months | 31 |
| It sailed from Iolcus | 21 |
| It sailed in 1492 | 17 |
| It sailed to Colchis | 20 |
| It sailed with the Nina | 23 |
| It sank in Havana Harbor | 24 |
| It sank the Titanic | 19 |
| It says "Hello" | 25 |
| It says "WILL CROSS WORDS 4 $$" on my blog picture | 60 |
| It scans for problems | 21 |
| It seals the deal | 17 |
| It seals up your buns | 21 |
| It seats 55,300 | 15 |
| It seats 55,601 | 15 |
| It seats four or more | 21 |
| It seats more than a coupe | 26 |
| It secures a nut | 16 |
| It seemingly crushes everything in its way | 42 |
| It seemingly never ends | 23 |
| It seems all the great comics have them | 39 |
| It seems like forever | 21 |
| It seems like it'll never end | 33 |
| It seems to pray over its prey | 30 |
| It sees across the border | 25 |
| It sees things | 14 |
| It seldom made Cerf bored | 25 |
| It sells | 8 |
| It sells a lot of build-it-yourself furniture | 45 |
| It sells in advertising, they say | 33 |
| It sells, apparently | 20 |
| It sells, it's said | 23 |
| It sells, reportedly | 20 |
| It sells, they say | 18 |
| It sends checks to A.A.R.P. members | 35 |
| It sends Olympians flying | 25 |
| It sends out lots of streams | 28 |
| It sends people on trips | 24 |
| It sent Dorothy to Oz | 21 |
| It sent Timothy Leary on a trip | 31 |
| It separated from the Czech Republic in 1993 | 44 |
| It separated Martin from Lewis | 30 |
| It separates ''pay'' from ''view'' | 66 |
| It separates actors from audiences | 34 |
| It separates by means | 21 |
| It separates by means? | 22 |
| It separates countries | 22 |
| It separates dollars and cents | 30 |
| It separates hours from minutes | 31 |
| It separates inlaws at the wedding | 34 |
| It separates Kazakhstan and Uzbekistan | 38 |
| It separates McEnroe from Borg | 30 |
| It separates money and everything | 33 |
| It separates seeds | 18 |
| It separates Sicily from the rest of Italy | 42 |
| It separates the Bering Sea from the Pacific | 44 |
| It separates the girls from the boys | 36 |
| It separates the lead singer from the band? | 43 |
| It separates the men from the boys | 34 |
| It separates two breaks | 23 |
| It separates two names | 22 |
| It served the Mid-Atlantic until 1976 | 37 |
| It serves a duel purpose | 24 |
| It serves as a reminder | 23 |
| It serves Jerusalem | 19 |
| It serves many courses: Abbr. | 29 |
| It serves no useful purpose | 27 |
| It serves Stockholm | 19 |
| It serves Tel Aviv | 18 |
| It serves the telly | 19 |
| It set sail from Iolcus | 23 |
| It set sail in 1492 | 19 |
| It sets off a ringtone | 22 |
| It sets off dynamite | 20 |
| It sets off the alarm | 21 |
| It sets standards for attys. | 28 |
| It sets the agenda | 18 |
| It sets the scene | 17 |
| It sets the tone | 16 |
| It sets things apart | 20 |
| It sets things off | 18 |
| It settles indoors | 18 |
| It settles on petals | 20 |
| It settles on sweeps | 20 |
| It settles the score | 20 |
| IT setups | 9 |
| It shares a 45-mile border with Canada | 38 |
| It shares a border with Montana | 31 |
| It shares a border with Switzerland | 35 |
| It shares a flag with Formentera | 32 |
| It shares a key with 8 | 22 |
| It shares a key with the slash | 30 |