| Issues an advisory | 18 |
| Issues an invitation | 20 |
| Issues cards | 12 |
| Issues for fashionable readers | 30 |
| Issues forth | 12 |
| Issues in paperback, perhaps | 28 |
| Issues of the DMV | 17 |
| Issues orders | 13 |
| Issues requiring attention | 26 |
| Issues, as a publication | 24 |
| Issues: Abbr. | 13 |
| Issuing forth | 13 |
| Issuing from a source | 21 |
| Issuing, as from a source | 25 |
| Issur Danielovitch | 18 |
| Issy infinitive | 15 |
| Issy intimate | 13 |
| Issyk ___, U.S.S.R. lake | 24 |
| Ist or 2nd book of the Bible | 28 |
| Istanbul bigwig | 15 |
| Istanbul brass | 14 |
| Istanbul coin | 13 |
| Istanbul coins | 14 |
| Istanbul currency | 17 |
| Istanbul denizen | 16 |
| Istanbul district | 17 |
| Istanbul harness races? | 23 |
| Istanbul honorific | 18 |
| Istanbul infant? | 16 |
| Istanbul inhabitant | 19 |
| Istanbul inn | 12 |
| Istanbul money | 14 |
| Istanbul native | 15 |
| Istanbul natives | 16 |
| Istanbul resident | 17 |
| Istanbul residents | 18 |
| Istanbul shelter | 16 |
| Istanbul sight | 14 |
| Istanbul title | 14 |
| Istanbul's ___ Airport | 26 |
| Isthmus | 7 |
| Isthmus land | 12 |
| Isthmus locale | 14 |
| Isthmus of Thailand | 19 |
| Isthmus of ___, Malay peninsula | 31 |
| Isthmus of ___, Thailand | 24 |
| Isthmus or monkey | 17 |
| Isthmuses | 9 |
| Istle product | 13 |
| ISU site | 8 |
| Isuzu model | 11 |
| Isuzu Rodeo, e.g. | 17 |
| Isuzu SUV | 9 |
| It in Italia | 13 |
| It 'blows no good' | 26 |
| It "ain't what it used to be": Yogi Berra | 55 |
| It "blows no good" | 28 |
| It "clings cruelly to us," according to Keats | 55 |
| It "comes on little cat feet," in a Sandburg poem | 59 |
| It "conquers all" | 27 |
| It "delights by affording a shadow of the pleasure which exists in pain," according to Shelley | 104 |
| It "deserves another" | 31 |
| It "enables us to find ourselves and lose ourselves at the same time": Merton | 87 |
| It "gives you something to do, but it gets you nowhere": Glenn Turner | 79 |
| It "goeth its way on triple feet": Aeschylus | 54 |
| It "has fleas" in an old ditty | 40 |
| It "has its reasons which reason knows nothing of": Pascal | 68 |
| It "hath charms" | 26 |
| It "hits the spot" per an old jingle | 46 |
| It "hits the spot," per old radio ads | 47 |
| It "is easy, and has infinite forms," according to Blaise Pascal | 74 |
| It "is no problem. You just have to live long enough": Groucho Marx | 77 |
| It "is nothing but perception," wrote Plato | 53 |
| It "isn't what it used to be": Peter De Vries | 59 |
| It "isn't what it used to be," said Simone Signoret | 65 |
| It "kills" some people | 32 |
| It "makes the world go round" | 39 |
| It "maketh many friends," according to the Bible | 58 |
| It "marches on its stomach" | 37 |
| It "marches on its stomach": Napoleon | 47 |
| It "never won any battle," according to Eisenhower | 60 |
| It "often gives a small thing a big shadow": old proverb | 66 |
| It "passeth all understanding": Philippians | 53 |
| It "signals" the way | 30 |
| It "slayeth the silly one": Job | 41 |
| It "sounds like a bunch of Italian chefs screaming risotto recipes at each other," according to Aristotle Onassis | 123 |
| It "springs eternal" | 30 |
| It "Stands Still" to Rush | 35 |
| It "sweeps clean" | 27 |
| It "waits at the crossway of the stars," wrote Borges | 63 |
| It "went to market" | 29 |
| It (1961) | 9 |
| It absorbed data from Funk and Wagnalls, among others | 53 |
| It abuts Armenia | 16 |
| It abuts Bhutan | 15 |
| It abuts the bema | 17 |
| It abuts the bema, sometimes | 28 |
| It abuts Tibet | 14 |
| It abuts Turkey | 15 |
| It accepts all ships | 20 |