| Loser of a footrace with Hippomenes | 35 |
| Loser of the "golden apples" race | 43 |
| Loser to "Cabaret" for Best Musical | 45 |
| Loser to Affirmed in all three Triple Crown races | 49 |
| Loser to Al Pacino for Best Actor of 1992 | 41 |
| Loser to Apollo Creed in their first bout | 41 |
| Loser to Audrey for the 1953 Best Actress Oscar | 47 |
| Loser to Björn in the 1976 Wimbledon final | 45 |
| Loser to Bon Homme Richard: 1779 | 32 |
| Loser to Eisenhower: 1952 and 1956 | 34 |
| Loser to Ghana in the 2010 World Cup | 36 |
| Loser to Happy Feet at the 2007 Oscars | 38 |
| Loser to Israel's Barak in 1999 | 35 |
| Loser to Nastase at the 1972 U.S. Open finals | 45 |
| Loser to paper and winner over scissors | 39 |
| Loser to Penn State: 1982 Sugar Bowl | 36 |
| Loser to Sheridan in the Shenandoah Valley | 42 |
| Loser to Sparta in the Peloponnesian War | 40 |
| Losers in the Battle of Horseshoe Bend | 38 |
| Losers of the Battle of Meloria, 1284 | 37 |
| Losers on "The Apprentice"? | 37 |
| Losers to BOS in the 2010 NBA playoffs | 38 |
| Losers to the 49ers in Super Bowl XXIII | 39 |
| Losers to the Rangers for the 1994 Stanley Cup | 46 |
| Losers to the Yankees in the 1998 Series | 40 |
| Losers, in an anti-drug campaign | 32 |
| Loses control on a snowy road, say | 34 |
| Loses energy, with "down" | 35 |
| Loses focus, with "out" | 33 |
| Loses ignominiously, on a game show | 35 |
| Loses one's footing at the car wash? | 40 |
| Loses weight (with "down") | 36 |
| Loses weight, with "down" | 35 |
| Loses what was originally put down? | 35 |
| Loses, in a way, with "down" | 38 |
| Losing a record deal, for example | 33 |
| Losing at checkers in a thunderstorm? | 37 |
| Losing athlete's demand, sometimes | 38 |
| Losing combination in a word game | 33 |
| Losing electorate's oxymoron? | 33 |
| Losing general at Spotsylvania Courthouse | 41 |
| Losing line in a children's game | 36 |
| Losing line on "Hollywood Squares" | 44 |
| Losing one's ability to be shocked? | 39 |
| Losing one's mind after getting lost? | 41 |
| Losing player in the 2005 World Series | 38 |
| Losing sch. in the second Sugar Bowl | 36 |
| Losing side in a 2000 Supreme Court ruling | 42 |
| Losing Super Bowl XIV team member | 33 |
| Losing tic-tac-toe line, perhaps | 32 |
| Loss caused by emigration for profit | 36 |
| Loss of power to understand words | 33 |
| Loss of power to use or understand words | 40 |
| Losses involving getting to the quarterback | 43 |
| Lost empire in a 2001 Disney title | 34 |
| Lost focus, with "out" | 32 |
| Lost in haze, like some Appalachian mountains | 45 |
| Lost in the Trees "___ Here Nor There" | 48 |
| Lost kite's location, at times | 34 |
| Lost lady in "The Raven" | 34 |
| Lost love in "The Raven" | 34 |
| Lost love in Poe's "The Raven" | 44 |
| Lost money on "Jeopardy!" e.g. | 40 |
| Lost pencils are sometimes found behind these | 45 |
| Lost sight of, as a religious goal | 34 |
| Lost subject of a hit Beatles song? | 35 |
| Lost tour group in South Pacific site? | 38 |
| Lost ___ ("Peter Pan" group) | 38 |
| Lost, as the lead/ withstand/ naturalness | 41 |
| Lost, but not forgotten, in brief | 33 |
| Lothario at a music awards ceremony? | 36 |
| Lotharios' lines in a singles bar? | 38 |
| Lotion for shoulder pain, perhaps | 33 |
| Lots of "Deck the Halls" | 34 |
| Lots of bands played "Live at the ___" | 48 |
| Lots of caresses, e.g., for short | 33 |
| Lots of people have seen her strip | 34 |
| Lots of these can be found on lots | 34 |
| Lott's party-leading counterpart | 36 |
| Lotte of ''The Threepenny Opera'' | 49 |
| Lotte of "From Russia with Love" | 42 |
| Lotte of "The Threepenny Opera" | 41 |
| Lottery player's cry of elation | 35 |
| Lottery player's exultant cry | 33 |
| Lottery player's happy shout | 32 |
| Lottery ticket that's also a coupon? | 40 |
| Lottery tickets with computer-generated numbers? | 48 |
| Lottery winner's announcement, maybe | 40 |
| Lottery winner's reaction, perhaps? | 39 |
| Lotus ___ (listless race in Greek myth) | 39 |
| Lotus-___ ("Odyssey" figure) | 38 |
| Lou Bega "A Little ___ Mambo" | 39 |
| Lou Bega's "___ No. 5" | 36 |
| Lou Diamond Phillips film of '88 | 36 |
| Lou Ferrigno role (with "The") | 40 |
| Lou Ferrigno role, with "The" | 39 |
| Lou Gehrig nickname, with "the" | 41 |
| Lou Gehrig's disease, alternatively | 39 |
| Lou Gehrig's disease, briefly | 33 |
| Lou Gehrig's disease, for short | 35 |